eF-site ID 4u5c-D PDB Code 4u5c Chain D click to enlarge Title Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex Classification Transport protein/toxin Compound Glutamate receptor 2 Source (CONII_CONST) Sequence D:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVVTLTSGLEQKTVVVTTILESPYVMMKKN HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG ARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVIDF SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVF AYILVSVVLFLVSRADISPRSLSARIVAGVWWFFTLIIIS SYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGS TKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVR KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI ATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECG AKDSALSLSNVAGVFYILVGGLGLAMLVALIEF Description Functional site 1) chain D residue 525-545 type SITE sequence IWMAIVFAYILVSVVLFLVSR description Interaction with glutamate receptor 2 (GRIA2) => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI1 2) chain D residue 603-623 type SITE sequence GVWWFFTLIIISSYTANLAAF description Interaction with glutamate receptor 2 (GRIA2) => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI1 3) chain D residue 669 type MOD_RES sequence K description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI10 4) chain D residue 703 type MOD_RES sequence L description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI11 5) chain D residue 596 type LIPID sequence L description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI12 6) chain D residue 237 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI13 7) chain D residue 351 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI14 8) chain D residue 394 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI15 9) chain D residue 597-602 type TOPO_DOM sequence SARIVA description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 10) chain D residue 594-596 type INTRAMEM sequence RSL description source Swiss-Prot : SWS_FT_FI4 11) chain D residue 624-798 type TOPO_DOM sequence LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLG TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSALSLS NVAGVFYI description Extracellular source Swiss-Prot : SWS_FT_FI5 12) chain D residue 480 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 13) chain D residue 482 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 14) chain D residue 487 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 15) chain D residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 16) chain D residue 662 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 17) chain D residue 712 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 18) chain D residue 455 type SITE sequence A description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI8 19) chain D residue 667 type SITE sequence F description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI8 20) chain D residue 759 type SITE sequence L description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI8 21) chain D residue 640 type SITE sequence S description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9

Display surface Download Links