eF-site ID 4u5c-D
PDB Code 4u5c
Chain D

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Title Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex
Classification Transport protein/toxin
Compound Glutamate receptor 2
Source (CONII_CONST)
Sequence D:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN
LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC
GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ
WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN
NDKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVI
TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD
YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV
QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI
ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR
KIGYWSEVDKMVVTLTSGLEQKTVVVTTILESPYVMMKKN
HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG
ARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVF
AYILVSVVLFLVSRADISPRSLSARIVAGVWWFFTLIIIS
SYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGS
TKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVR
KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI
ATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECG
AKDSALSLSNVAGVFYILVGGLGLAMLVALIEF
Description


Functional site

1) chain D
residue 525-545
type SITE
sequence IWMAIVFAYILVSVVLFLVSR
description Interaction with glutamate receptor 2 (GRIA2) => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI1

2) chain D
residue 603-623
type SITE
sequence GVWWFFTLIIISSYTANLAAF
description Interaction with glutamate receptor 2 (GRIA2) => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI1

3) chain D
residue 669
type MOD_RES
sequence K
description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
source Swiss-Prot : SWS_FT_FI10

4) chain D
residue 703
type MOD_RES
sequence L
description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
source Swiss-Prot : SWS_FT_FI11

5) chain D
residue 596
type LIPID
sequence L
description S-palmitoyl cysteine => ECO:0000250
source Swiss-Prot : SWS_FT_FI12

6) chain D
residue 237
type CARBOHYD
sequence E
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873
source Swiss-Prot : SWS_FT_FI13

7) chain D
residue 351
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI14

8) chain D
residue 394
type CARBOHYD
sequence T
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI15

9) chain D
residue 597-602
type TOPO_DOM
sequence SARIVA
description Cytoplasmic
source Swiss-Prot : SWS_FT_FI2

10) chain D
residue 594-596
type INTRAMEM
sequence RSL
description
source Swiss-Prot : SWS_FT_FI4

11) chain D
residue 624-798
type TOPO_DOM
sequence LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK
IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL
LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLG
TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSALSLS
NVAGVFYI
description Extracellular
source Swiss-Prot : SWS_FT_FI5

12) chain D
residue 480
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

13) chain D
residue 482
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

14) chain D
residue 487
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

15) chain D
residue 661
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

16) chain D
residue 662
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

17) chain D
residue 712
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

18) chain D
residue 455
type SITE
sequence A
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI8

19) chain D
residue 667
type SITE
sequence F
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI8

20) chain D
residue 759
type SITE
sequence L
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI8

21) chain D
residue 640
type SITE
sequence S
description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI9


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