eF-site ID 4u5c-C PDB Code 4u5c Chain C click to enlarge Title Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex Classification Transport protein/toxin Compound Glutamate receptor 2 Source (CONII_CONST) Sequence C:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVVTLTTSGLEQKTVVVTTILESPYVMMKK NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY GARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVID FSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIV FAYILVSVVLFLVSPRSLSARIVAGVWWFFTLIIISSYTA NLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEF FRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKG KYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK GSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSN VAGVFYILVGGLGLAMLVALIEFAY Description Functional site 1) chain C residue 452 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 2) chain C residue 487 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 3) chain C residue 712 type BINDING sequence I description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 4) chain C residue 480 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI8 5) chain C residue 351 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 6) chain C residue 387 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 7) chain C residue 394 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 8) chain C residue 482 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 9) chain C residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 10) chain C residue 662 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 11) chain C residue 596 type LIPID sequence L description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 12) chain C residue 237 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 13) chain C residue 455 type SITE sequence A description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 14) chain C residue 667 type SITE sequence F description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 15) chain C residue 759 type SITE sequence L description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 16) chain C residue 640 type SITE sequence S description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 17) chain C residue 669 type MOD_RES sequence K description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 18) chain C residue 703 type MOD_RES sequence L description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 19) chain C residue 597-602 type TOPO_DOM sequence SARIVA description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 20) chain C residue 594-596 type INTRAMEM sequence RSL description source Swiss-Prot : SWS_FT_FI4 21) chain C residue 624-798 type TOPO_DOM sequence LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLG TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNVAGVF YI description Extracellular source Swiss-Prot : SWS_FT_FI5

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