eF-site ID 4u5c-B
PDB Code 4u5c
Chain B

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Title Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex
Classification Transport protein/toxin
Compound Glutamate receptor 2
Source (CONII_CONST)
Sequence B:  SIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNL
EVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCG
TLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQW
DKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINN
DKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVIT
IGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDY
DDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQ
VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIE
RALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRK
IGYWSEVDKMVVTLTESGGLEQKTVVVTTILESPYVMMKK
NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY
GARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVID
FSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIV
FAYILVSVVLFLSPRSLSARIVAGVWWFFTLIIISSYTAN
LAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFF
RRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG
SSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNV
AGVFYILVGGLGLAMLVALIEFAYKR
Description


Functional site

1) chain B
residue 669
type MOD_RES
sequence K
description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
source Swiss-Prot : SWS_FT_FI10

2) chain B
residue 703
type MOD_RES
sequence L
description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
source Swiss-Prot : SWS_FT_FI11

3) chain B
residue 596
type LIPID
sequence L
description S-palmitoyl cysteine => ECO:0000250
source Swiss-Prot : SWS_FT_FI12

4) chain B
residue 237
type CARBOHYD
sequence E
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873
source Swiss-Prot : SWS_FT_FI13

5) chain B
residue 351
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI14

6) chain B
residue 394
type CARBOHYD
sequence T
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI15

7) chain B
residue 597-602
type TOPO_DOM
sequence SARIVA
description Cytoplasmic
source Swiss-Prot : SWS_FT_FI2

8) chain B
residue 594-596
type INTRAMEM
sequence RSL
description
source Swiss-Prot : SWS_FT_FI4

9) chain B
residue 624-798
type TOPO_DOM
sequence LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK
IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL
LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLG
TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNVAGVF
YI
description Extracellular
source Swiss-Prot : SWS_FT_FI5

10) chain B
residue 661
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

11) chain B
residue 662
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

12) chain B
residue 712
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

13) chain B
residue 480
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

14) chain B
residue 482
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

15) chain B
residue 487
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
source Swiss-Prot : SWS_FT_FI7

16) chain B
residue 455
type SITE
sequence A
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI8

17) chain B
residue 667
type SITE
sequence F
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI8

18) chain B
residue 759
type SITE
sequence L
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI8

19) chain B
residue 640
type SITE
sequence S
description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI9


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