eF-site ID 4u5c-B PDB Code 4u5c Chain B click to enlarge Title Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex Classification Transport protein/toxin Compound Glutamate receptor 2 Source (CONII_CONST) Sequence B:  SIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNL EVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCG TLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQW DKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINN DKKDETYRSLFQDLELKGERRVILDCERDKVNDIVDQVIT IGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDY DDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQ VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIE RALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRK IGYWSEVDKMVVTLTESGGLEQKTVVVTTILESPYVMMKK NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY GARDADTKIWDGMVGELVYGKADIAIAPLTITLVREEVID FSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIV FAYILVSVVLFLSPRSLSARIVAGVWWFFTLIIISSYTAN LAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFF RRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG SSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNV AGVFYILVGGLGLAMLVALIEFAYKR Description Functional site 1) chain B residue 669 type MOD_RES sequence K description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI10 2) chain B residue 703 type MOD_RES sequence L description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI11 3) chain B residue 596 type LIPID sequence L description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI12 4) chain B residue 237 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI13 5) chain B residue 351 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI14 6) chain B residue 394 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI15 7) chain B residue 597-602 type TOPO_DOM sequence SARIVA description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 8) chain B residue 594-596 type INTRAMEM sequence RSL description source Swiss-Prot : SWS_FT_FI4 9) chain B residue 624-798 type TOPO_DOM sequence LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLG TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSLSNVAGVF YI description Extracellular source Swiss-Prot : SWS_FT_FI5 10) chain B residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 11) chain B residue 662 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 12) chain B residue 712 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 13) chain B residue 480 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 14) chain B residue 482 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 15) chain B residue 487 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI7 16) chain B residue 455 type SITE sequence A description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI8 17) chain B residue 667 type SITE sequence F description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI8 18) chain B residue 759 type SITE sequence L description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI8 19) chain B residue 640 type SITE sequence S description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9

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