eF-site ID 4u5c-A PDB Code 4u5c Chain A click to enlarge Title Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex Classification Transport protein/toxin Compound Glutamate receptor 2 Source (CONII_CONST) Sequence A:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNID ETYRSLFQDLELKGERRVILDCERDKVNDIVDQVITIGKH VKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDYDDSL VSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTE AFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALK QVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYW SEVDKMVVTLTESGDGLEQKTVVVTTILESPYVMMKKNHE MLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR DADTKIWDGMVGELVYGKADIAIAPLTITLVREEVIDFSK PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAY ILVSVVLFLVSSPRSLSARIVAGVWWFFTLIIISSYTANL AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS SLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSALSLS NVAGVFYILVGGLGLAMLVALIEFAYK Description Functional site 1) chain A residue 596 type LIPID sequence L description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 2) chain A residue 237 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 3) chain A residue 351 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 4) chain A residue 394 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 5) chain A residue 597-602 type TOPO_DOM sequence SARIVA description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 6) chain A residue 594-596 type INTRAMEM sequence RSL description source Swiss-Prot : SWS_FT_FI4 7) chain A residue 624-798 type TOPO_DOM sequence LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLG TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGSALSLSNVA GVFYI description Extracellular source Swiss-Prot : SWS_FT_FI5 8) chain A residue 452 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 9) chain A residue 487 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 10) chain A residue 712 type BINDING sequence I description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 11) chain A residue 480 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI8 12) chain A residue 482 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 13) chain A residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 14) chain A residue 662 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 15) chain A residue 455 type SITE sequence A description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 16) chain A residue 667 type SITE sequence F description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 17) chain A residue 759 type SITE sequence L description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 18) chain A residue 640 type SITE sequence S description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 19) chain A residue 669 type MOD_RES sequence K description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 20) chain A residue 703 type MOD_RES sequence L description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13

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