eF-site ID 4u4g-B PDB Code 4u4g Chain B click to enlarge Title Structure of GluA2* in complex with competitive antagonist ZK 200775 Classification TRANSPORT PROTEIN Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence B:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVLTEDDTSGLEQKTVVVTTILESPYVMMK KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI DFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI VFAYIGVSVVLFLVSTNEFGIFNSLWFSLGAFMQPRSLSG RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED LSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE PSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPC DTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGV LDKLKNKWWYDKGECSALSLSNVAGVFYILVGGLGLAMLV ALIEFCYK Description Functional site 1) chain B residue 355 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 2) chain B residue 391 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 3) chain B residue 398 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 4) chain B residue 668 type MOD_RES sequence D description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 5) chain B residue 702 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 6) chain B residue 595 type LIPID sequence S description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 7) chain B residue 456 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 8) chain B residue 491 type BINDING sequence F description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 9) chain B residue 711 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 10) chain B residue 484 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI8 11) chain B residue 486 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 12) chain B residue 660 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 13) chain B residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 14) chain B residue 241 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 15) chain B residue 459 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 16) chain B residue 666 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 17) chain B residue 758 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 18) chain B residue 639 type SITE sequence L description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 19) chain B residue 602-622 type TRANSMEM sequence GGVWWFFTLIIISSYTANLAA description Helical source Swiss-Prot : SWS_FT_FI1 20) chain B residue 596-601 type TOPO_DOM sequence LSGRIV description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 21) chain B residue 593-595 type INTRAMEM sequence PRS description source Swiss-Prot : SWS_FT_FI4 22) chain B residue 623-797 type TOPO_DOM sequence FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSL GTPVNLAVLKLSEQGVLDKLKNKWWYDKGECSALSLSNVA GVFY description Extracellular source Swiss-Prot : SWS_FT_FI5

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