eF-site ID 4u4g-ABCD PDB Code 4u4g Chain A, B, C, D click to enlarge Title Structure of GluA2* in complex with competitive antagonist ZK 200775 Classification TRANSPORT PROTEIN Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence A:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVLTEDDTSGLEQKTVVVTTILESPYVMMK KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI DFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI VFAYIGVSVVLFLVSTNEFGIFNSLWFSLGAFMQPRSLSG RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED LSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE PSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPC DTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGV LDKLKNKWWYDKGECSALSLSNVAGVFYILVGGLGLAMLV ALIEFCYK B:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVLTEDDTSGLEQKTVVVTTILESPYVMMK KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI DFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI VFAYIGVSVVLFLVSTNEFGIFNSLWFSLGAFMQPRSLSG RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED LSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE PSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPC DTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGV LDKLKNKWWYDKGECSALSLSNVAGVFYILVGGLGLAMLV ALIEFCYK C:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVLTEDDTSGLEQKTVVVTTILESPYVMMK KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI DFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI VFAYIGVSVVLFLVSTNEFGIFNSLWFSLGAFMQPRSLSG RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED LSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE PSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPC DTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGV LDKLKNKWWYDKGECSALSLSNVAGVFYILVGGLGLAMLV ALIEFCYK D:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVLTEDDTSGLEQKTVVVTTILESPYVMMK KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI DFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI VFAYIGVSVVLFLVSTNEFGIFNSLWFSLGAFMQPRSLSG RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED LSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE PSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPC DTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGV LDKLKNKWWYDKGECSALSLSNVAGVFYILVGGLGLAMLV ALIEFCYK Description Functional site 1) chain A residue 355 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 2) chain B residue 355 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 3) chain C residue 355 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 4) chain D residue 355 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 5) chain A residue 391 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 6) chain A residue 398 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 7) chain B residue 391 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 8) chain B residue 398 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 9) chain C residue 391 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 10) chain C residue 398 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 11) chain D residue 391 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 12) chain D residue 398 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 13) chain A residue 668 type MOD_RES sequence D description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 14) chain B residue 668 type MOD_RES sequence D description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 15) chain C residue 668 type MOD_RES sequence D description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 16) chain D residue 668 type MOD_RES sequence D description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 17) chain A residue 702 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 18) chain B residue 702 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 19) chain C residue 702 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 20) chain D residue 702 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 21) chain A residue 595 type LIPID sequence S description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 22) chain B residue 595 type LIPID sequence S description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 23) chain C residue 595 type LIPID sequence S description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 24) chain D residue 595 type LIPID sequence S description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 25) chain A residue 456 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 26) chain D residue 456 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 27) chain D residue 491 type BINDING sequence F description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 28) chain D residue 711 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 29) chain A residue 491 type BINDING sequence F description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 30) chain A residue 711 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 31) chain B residue 456 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 32) chain B residue 491 type BINDING sequence F description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 33) chain B residue 711 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 34) chain C residue 456 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 35) chain C residue 491 type BINDING sequence F description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 36) chain C residue 711 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 37) chain A residue 484 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI8 38) chain B residue 484 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI8 39) chain C residue 484 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI8 40) chain D residue 484 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI8 41) chain A residue 486 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 42) chain D residue 486 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 43) chain D residue 660 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 44) chain D residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 45) chain A residue 660 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 46) chain A residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 47) chain B residue 486 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 48) chain B residue 660 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 49) chain B residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 50) chain C residue 486 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 51) chain C residue 660 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 52) chain C residue 661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 53) chain A residue 241 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 54) chain B residue 241 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 55) chain C residue 241 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 56) chain D residue 241 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 57) chain A residue 459 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 58) chain D residue 459 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 59) chain D residue 666 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 60) chain D residue 758 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 61) chain A residue 666 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 62) chain A residue 758 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 63) chain B residue 459 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 64) chain B residue 666 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 65) chain B residue 758 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 66) chain C residue 459 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 67) chain C residue 666 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 68) chain C residue 758 type SITE sequence V description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 69) chain A residue 639 type SITE sequence L description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 70) chain B residue 639 type SITE sequence L description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 71) chain C residue 639 type SITE sequence L description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 72) chain D residue 639 type SITE sequence L description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 73) chain A residue 602-622 type TRANSMEM sequence GGVWWFFTLIIISSYTANLAA description Helical source Swiss-Prot : SWS_FT_FI1 74) chain B residue 602-622 type TRANSMEM sequence GGVWWFFTLIIISSYTANLAA description Helical source Swiss-Prot : SWS_FT_FI1 75) chain C residue 602-622 type TRANSMEM sequence GGVWWFFTLIIISSYTANLAA description Helical source Swiss-Prot : SWS_FT_FI1 76) chain D residue 602-622 type TRANSMEM sequence GGVWWFFTLIIISSYTANLAA description Helical source Swiss-Prot : SWS_FT_FI1 77) chain A residue 596-601 type TOPO_DOM sequence LSGRIV description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 78) chain B residue 596-601 type TOPO_DOM sequence LSGRIV description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 79) chain C residue 596-601 type TOPO_DOM sequence LSGRIV description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 80) chain D residue 596-601 type TOPO_DOM sequence LSGRIV description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 81) chain A residue 593-595 type INTRAMEM sequence PRS description source Swiss-Prot : SWS_FT_FI4 82) chain B residue 593-595 type INTRAMEM sequence PRS description source Swiss-Prot : SWS_FT_FI4 83) chain C residue 593-595 type INTRAMEM sequence PRS description source Swiss-Prot : SWS_FT_FI4 84) chain D residue 593-595 type INTRAMEM sequence PRS description source Swiss-Prot : SWS_FT_FI4 85) chain A residue 623-797 type TOPO_DOM sequence FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSL GTPVNLAVLKLSEQGVLDKLKNKWWYDKGECSALSLSNVA GVFY description Extracellular source Swiss-Prot : SWS_FT_FI5 86) chain B residue 623-797 type TOPO_DOM sequence FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSL GTPVNLAVLKLSEQGVLDKLKNKWWYDKGECSALSLSNVA GVFY description Extracellular source Swiss-Prot : SWS_FT_FI5 87) chain C residue 623-797 type TOPO_DOM sequence FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSL GTPVNLAVLKLSEQGVLDKLKNKWWYDKGECSALSLSNVA GVFY description Extracellular source Swiss-Prot : SWS_FT_FI5 88) chain D residue 623-797 type TOPO_DOM sequence FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSL GTPVNLAVLKLSEQGVLDKLKNKWWYDKGECSALSLSNVA GVFY description Extracellular source Swiss-Prot : SWS_FT_FI5

Display surface Download Links