eF-site ID 4u21-B PDB Code 4u21 Chain B click to enlarge Title GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E Classification Transport Protein, Membrane Protein Compound Glutamate receptor 2,Glutamate receptor 2 Source null (GRIA2_RAT) Sequence B:  NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAE IAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGK ADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIE SAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYM RSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ RKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLS EQGVLDKLKNKWWYDKGECG Description Functional site 1) chain B residue 61 type sequence Y description binding site for residue FWD B 401 source : AC2 2) chain B residue 89 type sequence P description binding site for residue FWD B 401 source : AC2 3) chain B residue 90 type sequence L description binding site for residue FWD B 401 source : AC2 4) chain B residue 91 type sequence T description binding site for residue FWD B 401 source : AC2 5) chain B residue 96 type sequence R description binding site for residue FWD B 401 source : AC2 6) chain B residue 138 type sequence L description binding site for residue FWD B 401 source : AC2 7) chain B residue 141 type sequence G description binding site for residue FWD B 401 source : AC2 8) chain B residue 142 type sequence S description binding site for residue FWD B 401 source : AC2 9) chain B residue 143 type sequence T description binding site for residue FWD B 401 source : AC2 10) chain B residue 174 type sequence T description binding site for residue FWD B 401 source : AC2 11) chain B residue 192 type sequence L description binding site for residue FWD B 401 source : AC2 12) chain B residue 193 type sequence E description binding site for residue FWD B 401 source : AC2 13) chain B residue 196 type sequence M description binding site for residue FWD B 401 source : AC2 14) chain B residue 92 type sequence I description binding site for residue FWF B 402 source : AC3 15) chain B residue 104 type sequence K description binding site for residue FWF B 402 source : AC3 16) chain B residue 105 type sequence P description binding site for residue FWF B 402 source : AC3 17) chain B residue 107 type sequence M description binding site for residue FWF B 402 source : AC3 18) chain B residue 217 type sequence S description binding site for residue FWF B 402 source : AC3 19) chain B residue 218 type sequence K description binding site for residue FWF B 402 source : AC3 20) chain B residue 219 type sequence G description binding site for residue FWF B 402 source : AC3 21) chain B residue 61 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 27) chain B residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI5 28) chain B residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI6 29) chain B residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI7 30) chain B residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 31) chain B residue 89 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 32) chain B residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 33) chain B residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 34) chain B residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3

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