eF-site ID 4u21-AB PDB Code 4u21 Chain A, B click to enlarge Title GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E Classification Transport Protein, Membrane Protein Compound Glutamate receptor 2,Glutamate receptor 2 Source Rattus norvegicus (Rat) (GRIA2_RAT) Sequence A:  ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAA EIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYG KADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPI ESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTY MRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE QRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKL SEQGVLDKLKNKWWYDKGECGS B:  NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAE IAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGK ADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIE SAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYM RSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ RKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLS EQGVLDKLKNKWWYDKGECG Description Functional site 1) chain A residue 61 type sequence Y description binding site for residue FWD A 401 source : AC1 2) chain A residue 89 type sequence P description binding site for residue FWD A 401 source : AC1 3) chain A residue 90 type sequence L description binding site for residue FWD A 401 source : AC1 4) chain A residue 91 type sequence T description binding site for residue FWD A 401 source : AC1 5) chain A residue 96 type sequence R description binding site for residue FWD A 401 source : AC1 6) chain A residue 138 type sequence L description binding site for residue FWD A 401 source : AC1 7) chain A residue 141 type sequence G description binding site for residue FWD A 401 source : AC1 8) chain A residue 142 type sequence S description binding site for residue FWD A 401 source : AC1 9) chain A residue 143 type sequence T description binding site for residue FWD A 401 source : AC1 10) chain A residue 174 type sequence T description binding site for residue FWD A 401 source : AC1 11) chain A residue 192 type sequence L description binding site for residue FWD A 401 source : AC1 12) chain A residue 193 type sequence E description binding site for residue FWD A 401 source : AC1 13) chain A residue 196 type sequence M description binding site for residue FWD A 401 source : AC1 14) chain B residue 61 type sequence Y description binding site for residue FWD B 401 source : AC2 15) chain B residue 89 type sequence P description binding site for residue FWD B 401 source : AC2 16) chain B residue 90 type sequence L description binding site for residue FWD B 401 source : AC2 17) chain B residue 91 type sequence T description binding site for residue FWD B 401 source : AC2 18) chain B residue 96 type sequence R description binding site for residue FWD B 401 source : AC2 19) chain B residue 138 type sequence L description binding site for residue FWD B 401 source : AC2 20) chain B residue 141 type sequence G description binding site for residue FWD B 401 source : AC2 21) chain B residue 142 type sequence S description binding site for residue FWD B 401 source : AC2 22) chain B residue 143 type sequence T description binding site for residue FWD B 401 source : AC2 23) chain B residue 174 type sequence T description binding site for residue FWD B 401 source : AC2 24) chain B residue 192 type sequence L description binding site for residue FWD B 401 source : AC2 25) chain B residue 193 type sequence E description binding site for residue FWD B 401 source : AC2 26) chain B residue 196 type sequence M description binding site for residue FWD B 401 source : AC2 27) chain A residue 92 type sequence I description binding site for residue FWF B 402 source : AC3 28) chain A residue 104 type sequence K description binding site for residue FWF B 402 source : AC3 29) chain A residue 105 type sequence P description binding site for residue FWF B 402 source : AC3 30) chain A residue 107 type sequence M description binding site for residue FWF B 402 source : AC3 31) chain A residue 108 type sequence S description binding site for residue FWF B 402 source : AC3 32) chain A residue 217 type sequence S description binding site for residue FWF B 402 source : AC3 33) chain A residue 218 type sequence K description binding site for residue FWF B 402 source : AC3 34) chain A residue 219 type sequence G description binding site for residue FWF B 402 source : AC3 35) chain B residue 92 type sequence I description binding site for residue FWF B 402 source : AC3 36) chain B residue 104 type sequence K description binding site for residue FWF B 402 source : AC3 37) chain B residue 105 type sequence P description binding site for residue FWF B 402 source : AC3 38) chain B residue 107 type sequence M description binding site for residue FWF B 402 source : AC3 39) chain B residue 217 type sequence S description binding site for residue FWF B 402 source : AC3 40) chain B residue 218 type sequence K description binding site for residue FWF B 402 source : AC3 41) chain B residue 219 type sequence G description binding site for residue FWF B 402 source : AC3 42) chain A residue 89 type BINDING sequence P description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 43) chain B residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 44) chain B residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 45) chain B residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 46) chain A residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 47) chain A residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 48) chain A residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 49) chain A residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 50) chain A residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 51) chain B residue 89 type BINDING sequence P description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 52) chain B residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 53) chain B residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 54) chain A residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 61) chain B residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 62) chain A residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI4 63) chain B residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI4 64) chain A residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI5 65) chain B residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI5 66) chain A residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 67) chain B residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6

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