eF-site ID 4u21-A PDB Code 4u21 Chain A click to enlarge Title GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E Classification Transport Protein, Membrane Protein Compound Glutamate receptor 2,Glutamate receptor 2 Source Rattus norvegicus (Rat) (GRIA2_RAT) Sequence A:  ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAA EIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYG KADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPI ESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTY MRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE QRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKL SEQGVLDKLKNKWWYDKGECGS Description Functional site 1) chain A residue 61 type sequence Y description binding site for residue FWD A 401 source : AC1 2) chain A residue 89 type sequence P description binding site for residue FWD A 401 source : AC1 3) chain A residue 90 type sequence L description binding site for residue FWD A 401 source : AC1 4) chain A residue 91 type sequence T description binding site for residue FWD A 401 source : AC1 5) chain A residue 96 type sequence R description binding site for residue FWD A 401 source : AC1 6) chain A residue 138 type sequence L description binding site for residue FWD A 401 source : AC1 7) chain A residue 141 type sequence G description binding site for residue FWD A 401 source : AC1 8) chain A residue 142 type sequence S description binding site for residue FWD A 401 source : AC1 9) chain A residue 143 type sequence T description binding site for residue FWD A 401 source : AC1 10) chain A residue 174 type sequence T description binding site for residue FWD A 401 source : AC1 11) chain A residue 192 type sequence L description binding site for residue FWD A 401 source : AC1 12) chain A residue 193 type sequence E description binding site for residue FWD A 401 source : AC1 13) chain A residue 196 type sequence M description binding site for residue FWD A 401 source : AC1 14) chain A residue 92 type sequence I description binding site for residue FWF B 402 source : AC3 15) chain A residue 104 type sequence K description binding site for residue FWF B 402 source : AC3 16) chain A residue 105 type sequence P description binding site for residue FWF B 402 source : AC3 17) chain A residue 107 type sequence M description binding site for residue FWF B 402 source : AC3 18) chain A residue 108 type sequence S description binding site for residue FWF B 402 source : AC3 19) chain A residue 217 type sequence S description binding site for residue FWF B 402 source : AC3 20) chain A residue 218 type sequence K description binding site for residue FWF B 402 source : AC3 21) chain A residue 219 type sequence G description binding site for residue FWF B 402 source : AC3 22) chain A residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 23) chain A residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI5 27) chain A residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI6 28) chain A residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI7 29) chain A residue 61 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 89 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 33) chain A residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 34) chain A residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 35) chain A residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3

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