eF-site ID 4u1x-C PDB Code 4u1x Chain C click to enlarge Title Full length GluA2-kainate-(R,R)-2b complex crystal form B Classification Transport protein, Membrane protein Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence C:  SIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNL EVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCG TLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQW DKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINN DKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVIT IGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVDY DDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQ VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIE RALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRK IGYWSEVDKMVVTLTELEQKTVVVTTILESPYVMMKKNHE MLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR DADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAY ILVSVVLFLVSRFPRSLSARIVAGVWWFFTLIIISSYTAN LAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFF RRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG SSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSG SKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF Description Functional site 1) chain C residue 593 type LIPID sequence P description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 2) chain C residue 239 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 3) chain C residue 600-620 type TRANSMEM sequence IVAGVWWFFTLIIISSYTANL description Helical source Swiss-Prot : SWS_FT_FI1 4) chain C residue 594-599 type TOPO_DOM sequence RSLSAR description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 5) chain C residue 621-795 type TOPO_DOM sequence AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS SLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGS KEKTSALSLSNVAGV description Extracellular source Swiss-Prot : SWS_FT_FI5 6) chain C residue 457 type SITE sequence T description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 7) chain C residue 664 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 8) chain C residue 756 type SITE sequence Q description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 9) chain C residue 637 type SITE sequence E description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 10) chain C residue 666 type MOD_RES sequence V description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 11) chain C residue 353 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 12) chain C residue 396 type CARBOHYD sequence V description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 13) chain C residue 700 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 14) chain C residue 454 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 15) chain C residue 489 type BINDING sequence I description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 16) chain C residue 709 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 17) chain C residue 482 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI8 18) chain C residue 484 type BINDING sequence V description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 19) chain C residue 658 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 20) chain C residue 659 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9

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