eF-site ID 4u1x-A PDB Code 4u1x Chain A click to enlarge Title Full length GluA2-kainate-(R,R)-2b complex crystal form B Classification Transport protein, Membrane protein Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence A:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVVTLTEDDTSGLEQKTVVVTTILESPYVM MKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGD GKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREE VIDFSKPFMSLGISIMIKKPQKFSFLDPLAYEIWMAIVFA YILVSVVLFLVSPRSLSARIVAGVWWFFTLIIISSYTANL AAFLTVERMSPIESAEDLSKQTEIAYGTLDSGSTKEFFRR SKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS LGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKSALSL SNVAGVFYILVGGLGLAMLVALI Description Functional site 1) chain A residue 593 type LIPID sequence P description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI14 2) chain A residue 239 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 3) chain A residue 353 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 4) chain A residue 389 type CARBOHYD sequence G description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 5) chain A residue 396 type CARBOHYD sequence V description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 6) chain A residue 600-620 type TRANSMEM sequence IVAGVWWFFTLIIISSYTANL description Helical source Swiss-Prot : SWS_FT_FI1 7) chain A residue 594-599 type TOPO_DOM sequence RSLSAR description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 8) chain A residue 621-795 type TOPO_DOM sequence AAFLTVERMSPIESAEDLSKQTEIAYGTLDSGSTKEFFRR SKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS LGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKSALSL SNVAGV description Extracellular source Swiss-Prot : SWS_FT_FI5 9) chain A residue 489 type BINDING sequence I description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 10) chain A residue 709 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 11) chain A residue 454 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 12) chain A residue 482 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI8 13) chain A residue 659 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 14) chain A residue 484 type BINDING sequence V description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 15) chain A residue 658 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 16) chain A residue 457 type SITE sequence T description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 17) chain A residue 664 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 18) chain A residue 756 type SITE sequence Q description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 19) chain A residue 637 type SITE sequence E description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 20) chain A residue 666 type MOD_RES sequence V description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 21) chain A residue 700 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13

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