eF-site ID 4u1w-D PDB Code 4u1w Chain D Title Full length GluA2-kainate-(R,R)-2b complex crystal form A Classification Transport protein, Membrane protein Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence D:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVVTLTEDDTSGLEQKTVVVTTILESPYVM MKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGD GKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREE VIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM AIVFAYIGVSVVLFLVSLSARIVAGVWWFFTLIIISSYTA NLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEF FRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKG KYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK GSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGATSA LSLSNVAGVFYILVGGLGLAMLVALIEFAY Description Functional site 1) chain D residue 600-620 type TRANSMEM sequence IVAGVWWFFTLIIISSYTANL description Helical source Swiss-Prot : SWS_FT_FI1 2) chain D residue 353 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 3) chain D residue 389 type CARBOHYD sequence G description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 4) chain D residue 396 type CARBOHYD sequence V description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 5) chain D residue 666 type MOD_RES sequence V description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 6) chain D residue 700 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 7) chain D residue 239 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 8) chain D residue 454 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 9) chain D residue 489 type BINDING sequence I description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 10) chain D residue 709 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 11) chain D residue 482 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI8 12) chain D residue 484 type BINDING sequence V description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 13) chain D residue 658 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 14) chain D residue 659 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 15) chain D residue 621-795 type TOPO_DOM sequence AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS SLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGATSALS LSNVAGV description Extracellular source Swiss-Prot : SWS_FT_FI5 16) chain D residue 796-816 type TRANSMEM sequence FYILVGGLGLAMLVALIEFAY description Helical; Name=M4 source Swiss-Prot : SWS_FT_FI6 17) chain D residue 457 type SITE sequence T description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 18) chain D residue 664 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 19) chain D residue 756 type SITE sequence Q description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 20) chain D residue 637 type SITE sequence E description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11

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