eF-site/Summary 4u1w-C

eF-site ID	4u1w-C
PDB Code	4u1w
Chain	C

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Title	Full length GluA2-kainate-(R,R)-2b complex crystal form A
Classification	Transport protein, Membrane protein
Compound	Glutamate receptor 2
Source	(GRIA2_RAT)

Sequence	C:	NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNIN NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI TIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAV QVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR KIGYWSEVDKMVVTLTEDDTSGLKTVVVTTILESPYVMMK KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI DFSKPFMSLGISIMIKKVFSFLDPLAYEIWMAIVFAYIGV SVVLFLVLSARIVAGVWWFFTLIIISSYTANLAAFLTVER MVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFD KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTM NEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNL AVLKLSEQGVLDKLKNKWWYDKGECGALSLSNVAGVFYIL VGGLGLAMLVALIEFA

Description

Functional site


1)	chain	C
	residue	600-620
	type	TRANSMEM
	sequence	IVAGVWWFFTLIIISSYTANL
	description	Helical
	source	Swiss-Prot : SWS_FT_FI1

2)	chain	C
	residue	353
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19946266, ECO:0000269\|PubMed:21317873, ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI16

3)	chain	C
	residue	389
	type	CARBOHYD
	sequence	G
	description	N-linked (GlcNAc...) asparagine => ECO:0000255
	source	Swiss-Prot : SWS_FT_FI17

4)	chain	C
	residue	396
	type	CARBOHYD
	sequence	V
	description	N-linked (GlcNAc...) asparagine => ECO:0000255
	source	Swiss-Prot : SWS_FT_FI17

5)	chain	C
	residue	666
	type	MOD_RES
	sequence	V
	description	Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293
	source	Swiss-Prot : SWS_FT_FI12

6)	chain	C
	residue	700
	type	MOD_RES
	sequence	Y
	description	Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293
	source	Swiss-Prot : SWS_FT_FI13

7)	chain	C
	residue	239
	type	CARBOHYD
	sequence	E
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:21317873
	source	Swiss-Prot : SWS_FT_FI15

8)	chain	C
	residue	454
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:16483599
	source	Swiss-Prot : SWS_FT_FI7

9)	chain	C
	residue	489
	type	BINDING
	sequence	I
	description	BINDING => ECO:0000269\|PubMed:16483599
	source	Swiss-Prot : SWS_FT_FI7

10)	chain	C
	residue	709
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:16483599
	source	Swiss-Prot : SWS_FT_FI7

11)	chain	C
	residue	482
	type	BINDING
	sequence	T
	description
	source	Swiss-Prot : SWS_FT_FI8

12)	chain	C
	residue	484
	type	BINDING
	sequence	V
	description	BINDING => ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI9

13)	chain	C
	residue	658
	type	BINDING
	sequence	F
	description	BINDING => ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI9

14)	chain	C
	residue	659
	type	BINDING
	sequence	F
	description	BINDING => ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI9

15)	chain	C
	residue	621-795
	type	TOPO_DOM
	sequence	AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS SLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGALSLSN VAGV
	description	Extracellular
	source	Swiss-Prot : SWS_FT_FI5

16)	chain	C
	residue	457
	type	SITE
	sequence	T
	description	Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI10

17)	chain	C
	residue	664
	type	SITE
	sequence	I
	description	Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI10

18)	chain	C
	residue	756
	type	SITE
	sequence	Q
	description	Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI10

19)	chain	C
	residue	637
	type	SITE
	sequence	E
	description	Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405
	source	Swiss-Prot : SWS_FT_FI11