eF-site ID 4u1w-A PDB Code 4u1w Chain A click to enlarge Title Full length GluA2-kainate-(R,R)-2b complex crystal form A Classification Transport protein, Membrane protein Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence A:  NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDN LEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFC GTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNKE RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTD GDLLKIQFGGAEVSGFQIVDYDDSLVSKFIERWSTLEEKE YPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQ NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEDEQ KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEI AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKP GVFSFLDPLAYEIWMAIVFAYIGVSVVLFLVSSLSARIVA GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVF VRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMK VGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKL KNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGG LGLAMLVALIE Description Functional site 1) chain A residue 353 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI16 2) chain A residue 396 type CARBOHYD sequence V description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI17 3) chain A residue 600-620 type TRANSMEM sequence IVAGVWWFFTLIIISSYTANL description Helical source Swiss-Prot : SWS_FT_FI1 4) chain A residue 454 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 5) chain A residue 489 type BINDING sequence I description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 6) chain A residue 709 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI7 7) chain A residue 482 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI8 8) chain A residue 659 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 9) chain A residue 484 type BINDING sequence V description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 10) chain A residue 658 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI9 11) chain A residue 457 type SITE sequence T description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 12) chain A residue 664 type SITE sequence I description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 13) chain A residue 756 type SITE sequence Q description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI10 14) chain A residue 637 type SITE sequence E description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI11 15) chain A residue 666 type MOD_RES sequence V description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI12 16) chain A residue 700 type MOD_RES sequence Y description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI13 17) chain A residue 239 type CARBOHYD sequence E description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 source Swiss-Prot : SWS_FT_FI15 18) chain A residue 621-795 type TOPO_DOM sequence AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS SLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGS KEKTSALSLSNVAGV description Extracellular source Swiss-Prot : SWS_FT_FI5

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