eF-site ID 4u07-B PDB Code 4u07 Chain B click to enlarge Title ATP bound to eukaryotic FIC domain containing protein Classification TRANSFERASE Compound Adenosine monophosphate-protein transferase FICD Source Homo sapiens (Human) (FICD_HUMAN) Sequence B:  AALNQALEMKRQGKREKAQKLFMHALKMDPDFVDALTEFG IFSEEDKDIIQADYLYTRALTISPYHEKALVNRDRTLPLV EEIDQRYFSIIDSKVKKVMSINSALRRVMEETYYHHIYHT VAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAA MKYINTTLVSRIGSVTISDVLEIHRRVLGYVDPVEAGRFR TTQVLVGHHIPPHPQDVEKQMQEFVQWLNSEEAMNLHPVE FAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPIT IRKEQRSDYYHVLEAANEGDVRPFIRFIAKCTETTLDTLL FAT Description Functional site 1) chain B residue 367 type sequence D description binding site for residue MG B 501 source : AC4 2) chain B residue 233 type sequence I description binding site for residue ATP B 502 source : AC5 3) chain B residue 234 type sequence E description binding site for residue ATP B 502 source : AC5 4) chain B residue 316 type sequence V description binding site for residue ATP B 502 source : AC5 5) chain B residue 319 type sequence H description binding site for residue ATP B 502 source : AC5 6) chain B residue 360 type sequence V description binding site for residue ATP B 502 source : AC5 7) chain B residue 363 type sequence H description binding site for residue ATP B 502 source : AC5 8) chain B residue 367 type sequence D description binding site for residue ATP B 502 source : AC5 9) chain B residue 368 type sequence G description binding site for residue ATP B 502 source : AC5 10) chain B residue 369 type sequence N description binding site for residue ATP B 502 source : AC5 11) chain B residue 370 type sequence G description binding site for residue ATP B 502 source : AC5 12) chain B residue 371 type sequence R description binding site for residue ATP B 502 source : AC5 13) chain B residue 374 type sequence R description binding site for residue ATP B 502 source : AC5 14) chain B residue 399 type sequence Y description binding site for residue ATP B 502 source : AC5 15) chain B residue 400 type sequence Y description binding site for residue ATP B 502 source : AC5 16) chain B residue 403 type sequence L description binding site for residue ATP B 502 source : AC5 17) chain B residue 407 type sequence N description binding site for residue ATP B 502 source : AC5 18) chain B residue 358 type sequence K description binding site for residue PG4 B 503 source : AC6 19) chain B residue 363 type ACT_SITE sequence H description ACT_SITE => ECO:0000269|PubMed:22266942 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 234 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07, ECO:0007744|PDB:4U0U source Swiss-Prot : SWS_FT_FI2 21) chain B residue 316 type BINDING sequence V description BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07, ECO:0007744|PDB:4U0S, ECO:0007744|PDB:4U0U source Swiss-Prot : SWS_FT_FI3 22) chain B residue 399 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07, ECO:0007744|PDB:4U0S, ECO:0007744|PDB:4U0U source Swiss-Prot : SWS_FT_FI3 23) chain B residue 407 type BINDING sequence N description BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07, ECO:0007744|PDB:4U0S, ECO:0007744|PDB:4U0U source Swiss-Prot : SWS_FT_FI3 24) chain B residue 367 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 234 type SITE sequence E description Important for autoinhibition of adenylyltransferase activity => ECO:0000269|PubMed:22266942, ECO:0000269|PubMed:25435325 source Swiss-Prot : SWS_FT_FI5 26) chain B residue 183 type MOD_RES sequence T description O-AMP-threonine; by autocatalysis => ECO:0000305|PubMed:25601083 source Swiss-Prot : SWS_FT_FI6 27) chain B residue 275 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:25601083 source Swiss-Prot : SWS_FT_FI7

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