eF-site ID 4tzc-D PDB Code 4tzc Chain D click to enlarge Title Crystal Structure of Murine Cereblon in Complex with Thalidomide Classification LIGASE Compound Protein cereblon Source Mus musculus (Mouse) (CRBN_MOUSE) Sequence D:  TSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHE TLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHI GWKFTATKKDMSPQKFWGLTRSALLPT Description Functional site 1) chain D residue 380 type sequence H description binding site for residue SO4 B 504 source : AD1 2) chain D residue 353 type sequence N description binding site for residue EF2 B 505 source : AD2 3) chain D residue 357 type sequence Y description binding site for residue EF2 B 505 source : AD2 4) chain D residue 382 type sequence W description binding site for residue EF2 B 505 source : AD2 5) chain D residue 325 type sequence C description binding site for residue ZN D 501 source : AD3 6) chain D residue 328 type sequence C description binding site for residue ZN D 501 source : AD3 7) chain D residue 393 type sequence C description binding site for residue ZN D 501 source : AD3 8) chain D residue 396 type sequence C description binding site for residue ZN D 501 source : AD3 9) chain D residue 366 type sequence K description binding site for residue SO4 D 502 source : AD4 10) chain D residue 403 type sequence K description binding site for residue SO4 D 502 source : AD4 11) chain D residue 415 type sequence K description binding site for residue SO4 D 502 source : AD4 12) chain D residue 417 type sequence W description binding site for residue SO4 D 502 source : AD4 13) chain D residue 366 type sequence K description binding site for residue SO4 D 503 source : AD5 14) chain D residue 415 type sequence K description binding site for residue SO4 D 503 source : AD5 15) chain D residue 413 type sequence P description binding site for residue SO4 D 504 source : AD6 16) chain D residue 414 type sequence Q description binding site for residue SO4 D 504 source : AD6 17) chain D residue 415 type sequence K description binding site for residue SO4 D 504 source : AD6 18) chain D residue 380 type sequence H description binding site for residue EF2 D 505 source : AD7 19) chain D residue 381 type sequence S description binding site for residue EF2 D 505 source : AD7 20) chain D residue 382 type sequence W description binding site for residue EF2 D 505 source : AD7 21) chain D residue 388 type sequence W description binding site for residue EF2 D 505 source : AD7 22) chain D residue 402 type sequence W description binding site for residue EF2 D 505 source : AD7 23) chain D residue 404 type sequence F description binding site for residue EF2 D 505 source : AD7 24) chain D residue 326 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 329 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 381 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 383 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 389 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 394 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 397 type BINDING sequence A description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1

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