eF-site ID 4tzc-C PDB Code 4tzc Chain C click to enlarge Title Crystal Structure of Murine Cereblon in Complex with Thalidomide Classification LIGASE Compound Protein cereblon Source Mus musculus (Mouse) (CRBN_MOUSE) Sequence C:  STSLCCKQCQETEITTKNEIFSLSVHETLTVYKASNLNLI GRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSP QKFWGLTRSALLP Description Functional site 1) chain C residue 325 type sequence C description binding site for residue ZN C 501 source : AC1 2) chain C residue 328 type sequence C description binding site for residue ZN C 501 source : AC1 3) chain C residue 393 type sequence C description binding site for residue ZN C 501 source : AC1 4) chain C residue 396 type sequence C description binding site for residue ZN C 501 source : AC1 5) chain C residue 380 type sequence H description binding site for residue EF2 C 502 source : AC2 6) chain C residue 381 type sequence S description binding site for residue EF2 C 502 source : AC2 7) chain C residue 382 type sequence W description binding site for residue EF2 C 502 source : AC2 8) chain C residue 388 type sequence W description binding site for residue EF2 C 502 source : AC2 9) chain C residue 402 type sequence W description binding site for residue EF2 C 502 source : AC2 10) chain C residue 404 type sequence F description binding site for residue EF2 C 502 source : AC2 11) chain C residue 366 type sequence K description binding site for residue SO4 A 502 source : AC4 12) chain C residue 403 type sequence K description binding site for residue SO4 A 502 source : AC4 13) chain C residue 415 type sequence K description binding site for residue SO4 A 502 source : AC4 14) chain C residue 417 type sequence W description binding site for residue SO4 A 502 source : AC4 15) chain C residue 380 type sequence H description binding site for residue SO4 A 503 source : AC5 16) chain C residue 361 type sequence T description binding site for residue EF2 A 504 source : AC6 17) chain C residue 382 type sequence W description binding site for residue EF2 A 504 source : AC6 18) chain C residue 413 type sequence P description binding site for residue SO4 D 502 source : AD4 19) chain C residue 414 type sequence Q description binding site for residue SO4 D 502 source : AD4 20) chain C residue 366 type sequence K description binding site for residue SO4 D 503 source : AD5 21) chain C residue 415 type sequence K description binding site for residue SO4 D 503 source : AD5 22) chain C residue 326 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 23) chain C residue 329 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 24) chain C residue 381 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 25) chain C residue 383 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 26) chain C residue 389 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 27) chain C residue 394 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 28) chain C residue 397 type BINDING sequence A description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1

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