eF-site ID 4tzc-ABCD PDB Code 4tzc Chain A, B, C, D click to enlarge Title Crystal Structure of Murine Cereblon in Complex with Thalidomide Classification LIGASE Compound Protein cereblon Source Mus musculus (Mouse) (CRBN_MOUSE) Sequence A:  TSLCCKQCQETEITTKNEIFSLSLETLTVYKASNLNLIGR PSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQK FWGLTRSALLP B:  TSLCCKQCQETEITTKNEIFSLSLCGPMGYVHETLTVYKA SNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTAT KKDMSPQKFWGLTRSALLPT C:  STSLCCKQCQETEITTKNEIFSLSVHETLTVYKASNLNLI GRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSP QKFWGLTRSALLP D:  TSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHE TLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHI GWKFTATKKDMSPQKFWGLTRSALLPT Description Functional site 1) chain C residue 325 type sequence C description binding site for residue ZN C 501 source : AC1 2) chain C residue 328 type sequence C description binding site for residue ZN C 501 source : AC1 3) chain C residue 393 type sequence C description binding site for residue ZN C 501 source : AC1 4) chain C residue 396 type sequence C description binding site for residue ZN C 501 source : AC1 5) chain A residue 361 type sequence T description binding site for residue EF2 C 502 source : AC2 6) chain A residue 382 type sequence W description binding site for residue EF2 C 502 source : AC2 7) chain C residue 380 type sequence H description binding site for residue EF2 C 502 source : AC2 8) chain C residue 381 type sequence S description binding site for residue EF2 C 502 source : AC2 9) chain C residue 382 type sequence W description binding site for residue EF2 C 502 source : AC2 10) chain C residue 388 type sequence W description binding site for residue EF2 C 502 source : AC2 11) chain C residue 402 type sequence W description binding site for residue EF2 C 502 source : AC2 12) chain C residue 404 type sequence F description binding site for residue EF2 C 502 source : AC2 13) chain A residue 325 type sequence C description binding site for residue ZN A 501 source : AC3 14) chain A residue 328 type sequence C description binding site for residue ZN A 501 source : AC3 15) chain A residue 393 type sequence C description binding site for residue ZN A 501 source : AC3 16) chain A residue 396 type sequence C description binding site for residue ZN A 501 source : AC3 17) chain A residue 413 type sequence P description binding site for residue SO4 A 502 source : AC4 18) chain A residue 414 type sequence Q description binding site for residue SO4 A 502 source : AC4 19) chain C residue 366 type sequence K description binding site for residue SO4 A 502 source : AC4 20) chain C residue 403 type sequence K description binding site for residue SO4 A 502 source : AC4 21) chain C residue 415 type sequence K description binding site for residue SO4 A 502 source : AC4 22) chain C residue 417 type sequence W description binding site for residue SO4 A 502 source : AC4 23) chain A residue 380 type sequence H description binding site for residue SO4 A 503 source : AC5 24) chain C residue 380 type sequence H description binding site for residue SO4 A 503 source : AC5 25) chain A residue 380 type sequence H description binding site for residue EF2 A 504 source : AC6 26) chain A residue 381 type sequence S description binding site for residue EF2 A 504 source : AC6 27) chain A residue 382 type sequence W description binding site for residue EF2 A 504 source : AC6 28) chain A residue 388 type sequence W description binding site for residue EF2 A 504 source : AC6 29) chain A residue 402 type sequence W description binding site for residue EF2 A 504 source : AC6 30) chain A residue 404 type sequence F description binding site for residue EF2 A 504 source : AC6 31) chain C residue 361 type sequence T description binding site for residue EF2 A 504 source : AC6 32) chain C residue 382 type sequence W description binding site for residue EF2 A 504 source : AC6 33) chain B residue 325 type sequence C description binding site for residue ZN B 501 source : AC7 34) chain B residue 328 type sequence C description binding site for residue ZN B 501 source : AC7 35) chain B residue 393 type sequence C description binding site for residue ZN B 501 source : AC7 36) chain B residue 396 type sequence C description binding site for residue ZN B 501 source : AC7 37) chain B residue 366 type sequence K description binding site for residue SO4 B 502 source : AC8 38) chain B residue 403 type sequence K description binding site for residue SO4 B 502 source : AC8 39) chain B residue 413 type sequence P description binding site for residue SO4 B 502 source : AC8 40) chain B residue 414 type sequence Q description binding site for residue SO4 B 502 source : AC8 41) chain B residue 415 type sequence K description binding site for residue SO4 B 502 source : AC8 42) chain B residue 417 type sequence W description binding site for residue SO4 B 502 source : AC8 43) chain B residue 366 type sequence K description binding site for residue SO4 B 503 source : AC9 44) chain B residue 366 type sequence K description binding site for residue SO4 B 503 source : AC9 45) chain B residue 366 type sequence K description binding site for residue SO4 B 503 source : AC9 46) chain B residue 415 type sequence K description binding site for residue SO4 B 503 source : AC9 47) chain B residue 415 type sequence K description binding site for residue SO4 B 503 source : AC9 48) chain B residue 415 type sequence K description binding site for residue SO4 B 503 source : AC9 49) chain B residue 380 type sequence H description binding site for residue SO4 B 504 source : AD1 50) chain D residue 380 type sequence H description binding site for residue SO4 B 504 source : AD1 51) chain B residue 379 type sequence V description binding site for residue EF2 B 505 source : AD2 52) chain B residue 380 type sequence H description binding site for residue EF2 B 505 source : AD2 53) chain B residue 381 type sequence S description binding site for residue EF2 B 505 source : AD2 54) chain B residue 382 type sequence W description binding site for residue EF2 B 505 source : AD2 55) chain B residue 388 type sequence W description binding site for residue EF2 B 505 source : AD2 56) chain B residue 402 type sequence W description binding site for residue EF2 B 505 source : AD2 57) chain B residue 404 type sequence F description binding site for residue EF2 B 505 source : AD2 58) chain D residue 353 type sequence N description binding site for residue EF2 B 505 source : AD2 59) chain D residue 357 type sequence Y description binding site for residue EF2 B 505 source : AD2 60) chain D residue 382 type sequence W description binding site for residue EF2 B 505 source : AD2 61) chain D residue 325 type sequence C description binding site for residue ZN D 501 source : AD3 62) chain D residue 328 type sequence C description binding site for residue ZN D 501 source : AD3 63) chain D residue 393 type sequence C description binding site for residue ZN D 501 source : AD3 64) chain D residue 396 type sequence C description binding site for residue ZN D 501 source : AD3 65) chain C residue 413 type sequence P description binding site for residue SO4 D 502 source : AD4 66) chain C residue 414 type sequence Q description binding site for residue SO4 D 502 source : AD4 67) chain D residue 366 type sequence K description binding site for residue SO4 D 502 source : AD4 68) chain D residue 403 type sequence K description binding site for residue SO4 D 502 source : AD4 69) chain D residue 415 type sequence K description binding site for residue SO4 D 502 source : AD4 70) chain D residue 417 type sequence W description binding site for residue SO4 D 502 source : AD4 71) chain A residue 366 type sequence K description binding site for residue SO4 D 503 source : AD5 72) chain A residue 415 type sequence K description binding site for residue SO4 D 503 source : AD5 73) chain C residue 366 type sequence K description binding site for residue SO4 D 503 source : AD5 74) chain C residue 415 type sequence K description binding site for residue SO4 D 503 source : AD5 75) chain D residue 366 type sequence K description binding site for residue SO4 D 503 source : AD5 76) chain D residue 415 type sequence K description binding site for residue SO4 D 503 source : AD5 77) chain A residue 366 type sequence K description binding site for residue SO4 D 504 source : AD6 78) chain A residue 415 type sequence K description binding site for residue SO4 D 504 source : AD6 79) chain D residue 413 type sequence P description binding site for residue SO4 D 504 source : AD6 80) chain D residue 414 type sequence Q description binding site for residue SO4 D 504 source : AD6 81) chain D residue 415 type sequence K description binding site for residue SO4 D 504 source : AD6 82) chain B residue 357 type sequence Y description binding site for residue EF2 D 505 source : AD7 83) chain B residue 361 type sequence T description binding site for residue EF2 D 505 source : AD7 84) chain B residue 382 type sequence W description binding site for residue EF2 D 505 source : AD7 85) chain D residue 380 type sequence H description binding site for residue EF2 D 505 source : AD7 86) chain D residue 381 type sequence S description binding site for residue EF2 D 505 source : AD7 87) chain D residue 382 type sequence W description binding site for residue EF2 D 505 source : AD7 88) chain D residue 388 type sequence W description binding site for residue EF2 D 505 source : AD7 89) chain D residue 402 type sequence W description binding site for residue EF2 D 505 source : AD7 90) chain D residue 404 type sequence F description binding site for residue EF2 D 505 source : AD7 91) chain B residue 381 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 383 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 93) chain B residue 389 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 94) chain B residue 394 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 95) chain B residue 397 type BINDING sequence A description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 96) chain D residue 326 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 97) chain D residue 329 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 98) chain D residue 381 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 99) chain D residue 383 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 100) chain D residue 389 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 101) chain D residue 394 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 102) chain D residue 397 type BINDING sequence A description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 103) chain C residue 326 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 104) chain C residue 329 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 105) chain C residue 381 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 106) chain C residue 383 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 107) chain C residue 389 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 108) chain C residue 394 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 109) chain C residue 397 type BINDING sequence A description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 110) chain A residue 326 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 111) chain A residue 329 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 112) chain A residue 381 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 113) chain A residue 383 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 114) chain A residue 389 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 115) chain A residue 394 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 116) chain A residue 397 type BINDING sequence A description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 117) chain B residue 326 type BINDING sequence K description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1 118) chain B residue 329 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25108355 source Swiss-Prot : SWS_FT_FI1

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