eF-site ID 4twk-A PDB Code 4twk Chain A click to enlarge Title Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1) Classification TRANSPORT PROTEIN Compound Potassium channel subfamily K member 2 Source Homo sapiens (Human) (KCNK2_HUMAN) Sequence A:  TINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQR TTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPL GNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKI FCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFI KWNVSQTKIRIISTIIFILFGCVLFVALPGWSALDAIYFV VITLTTIGFGDYVAGGSDIKPVVWFWILVGLAYFAAVLSM IGDWLRVISAENLYF Description Functional site 1) chain A residue 62-82 type TRANSMEM sequence ATVFKALEQPHEISQRTTIVI description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 172-192 type TRANSMEM sequence FLLAGVGDQLGTIFGKGIAKV description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 224-244 type TRANSMEM sequence ALPGWSALDAIYF description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 144-170 type INTRAMEM sequence GFGNISPRTEGGKIFCIIYALLGIPLF description Pore-forming; Name=Pore-forming 1 => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 134 type CARBOHYD sequence F description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 6) chain A residue 193-223 type TOPO_DOM sequence EDTFIKWNVSQTKIRIISTIIFILFGCVLFV description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 7) chain A residue 253-283 type INTRAMEM sequence GFGDYVAGGSDIKPVVWFWILVGLA description Pore-forming; Name=Pore-forming 2 => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 8) chain A residue 110 type CARBOHYD sequence I description N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:4TWK source Swiss-Prot : SWS_FT_FI5

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