eF-site ID 4tuu-A
PDB Code 4tuu
Chain A

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Title Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design
Classification TRANSFERASE
Compound Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Source Homo sapiens (Human) (PK3CA_HUMAN)
Sequence A:  NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNV
CKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLD
KGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIR
KKTRSMLYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIM
LGRMPNLMLMAKESLYSQLPMDCFTMPSYSRKSLWVINSA
LRIKILCATYVNVNDKIYVRTGIYHGGEPLCDNVNTQRVP
CSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKEEHCPLA
WGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTG
SNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE
AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEI
TEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQM
YCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL
TDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRI
GHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLN
RQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPD
FMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNW
ENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENI
WQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK
GFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI
LGIGDRHNSNIMVKDDGQLFHIDFGHFLDRVPFVLTQDFL
IVISTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLG
SGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDA
Description


Functional site

1) chain A
residue 801-815
type prosite
sequence FKNGDDLRQDMLTLQ
description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
source prosite : PS00915

2) chain A
residue 900-920
type prosite
sequence SCAGYCVATFILGIGDRHNSN
description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFILgIgDRHnsN
source prosite : PS00916

3) chain A
residue 776
type SITE
sequence K
description Implicated in the recognition of ATP as well as PIP2. Also crucial for autophosphorylation of the p85alpha subunit => ECO:0000305|PubMed:23936502
source Swiss-Prot : SWS_FT_FI1


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