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eF-site ID
|
4tuu-A |
PDB Code
|
4tuu |
Chain
|
A |
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click to enlarge
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Title
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Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design |
Classification
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TRANSFERASE |
Compound
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
Source
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Homo sapiens (Human) (PK3CA_HUMAN) |
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Sequence
|
A: |
NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNV
CKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLD
KGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIR
KKTRSMLYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIM
LGRMPNLMLMAKESLYSQLPMDCFTMPSYSRKSLWVINSA
LRIKILCATYVNVNDKIYVRTGIYHGGEPLCDNVNTQRVP
CSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKEEHCPLA
WGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTG
SNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE
AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEI
TEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQM
YCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL
TDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRI
GHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLN
RQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPD
FMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNW
ENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENI
WQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK
GFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI
LGIGDRHNSNIMVKDDGQLFHIDFGHFLDRVPFVLTQDFL
IVISTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLG
SGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDA
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Description
|
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Functional site
|
|
1)
|
chain |
A |
residue |
801-815 |
type |
prosite |
sequence |
FKNGDDLRQDMLTLQ
|
description |
PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
|
source |
prosite : PS00915
|
|
2)
|
chain |
A |
residue |
900-920 |
type |
prosite |
sequence |
SCAGYCVATFILGIGDRHNSN
|
description |
PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFILgIgDRHnsN
|
source |
prosite : PS00916
|
|
3)
|
chain |
A |
residue |
776 |
type |
SITE |
sequence |
K
|
description |
Implicated in the recognition of ATP as well as PIP2. Also crucial for autophosphorylation of the p85alpha subunit => ECO:0000305|PubMed:23936502
|
source |
Swiss-Prot : SWS_FT_FI1
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