|
|
eF-site ID
|
4tuu-A |
|
PDB Code
|
4tuu |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design |
|
Classification
|
TRANSFERASE |
|
Compound
|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
|
Source
|
Homo sapiens (Human) (PK3CA_HUMAN) |
|
|
Sequence
|
A: |
NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNV
CKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLD
KGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIR
KKTRSMLYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIM
LGRMPNLMLMAKESLYSQLPMDCFTMPSYSRKSLWVINSA
LRIKILCATYVNVNDKIYVRTGIYHGGEPLCDNVNTQRVP
CSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKEEHCPLA
WGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTG
SNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE
AGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEI
TEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQM
YCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL
TDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRI
GHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLN
RQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPD
FMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNW
ENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENI
WQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK
GFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI
LGIGDRHNSNIMVKDDGQLFHIDFGHFLDRVPFVLTQDFL
IVISTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLG
SGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDA
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
801-815 |
| type |
prosite |
| sequence |
FKNGDDLRQDMLTLQ
|
| description |
PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
|
| source |
prosite : PS00915
|
|
|
2)
|
chain |
A |
| residue |
900-920 |
| type |
prosite |
| sequence |
SCAGYCVATFILGIGDRHNSN
|
| description |
PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFILgIgDRHnsN
|
| source |
prosite : PS00916
|
|
|
3)
|
chain |
A |
| residue |
776 |
| type |
SITE |
| sequence |
K
|
| description |
Implicated in the recognition of ATP as well as PIP2. Also crucial for autophosphorylation of the p85alpha subunit => ECO:0000305|PubMed:23936502
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|