eF-site ID 4tu0-ABCD PDB Code 4tu0 Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER Classification VIRAL PROTEIN Compound Non-structural polyprotein 3 Source (4TU0) Sequence A:  HHAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVY KKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSE SEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGK DRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQM RT B:  HHAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVY KKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSE SEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGK DRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQM RT C:  APSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKK WPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSESE GDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDR LTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT D:  APSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKK WPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYSESE GDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDR LTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMR Description Functional site 1) chain B residue 35 type sequence V description binding site for residue PEG B 201 source : AC1 2) chain B residue 114 type sequence G description binding site for residue PEG B 201 source : AC1 3) chain C residue 24 type sequence A description binding site for residue PEG C 201 source : AC2 4) chain C residue 35 type sequence V description binding site for residue PEG C 201 source : AC2 5) chain C residue 110 type sequence L description binding site for residue PEG C 201 source : AC2 6) chain C residue 113 type sequence T description binding site for residue PEG C 201 source : AC2 7) chain C residue 114 type sequence G description binding site for residue PEG C 201 source : AC2 8) chain C residue 116 type sequence Y description binding site for residue PEG C 201 source : AC2 9) chain A residue 12 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 114 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 115 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 116 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 12 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 14) chain C residue 26 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 15) chain C residue 34 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 114 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 115 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 18) chain C residue 116 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 12 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 26 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 26 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 34 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 114 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 115 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 116 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 34 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 114 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 115 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 116 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 12 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 26 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 34 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19386706 source Swiss-Prot : SWS_FT_FI1

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