eF-site ID 4tti-E PDB Code 4tti Chain E click to enlarge Title Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 4 FMC molecules Classification TRANSFERASE Compound Purine nucleoside phosphorylase DeoD-type Source (DEOD_ECOLI) Sequence E:  ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVN NVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDF GVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRF KDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFY SPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTIC TVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK Description Functional site 1) chain E residue 43 type sequence R description binding site for residue PO4 B 301 source : AC3 2) chain E residue 101 type sequence R description binding site for residue SO4 C 304 source : AC7 3) chain E residue 220 type sequence T description binding site for residue SO4 C 304 source : AC7 4) chain E residue 221 type sequence F description binding site for residue SO4 C 304 source : AC7 5) chain E residue 20 type sequence G description binding site for residue PO4 E 301 source : AD2 6) chain E residue 87 type sequence R description binding site for residue PO4 E 301 source : AD2 7) chain E residue 89 type sequence G description binding site for residue PO4 E 301 source : AD2 8) chain E residue 90 type sequence S description binding site for residue PO4 E 301 source : AD2 9) chain E residue 220 type sequence T description binding site for residue SO4 E 302 source : AD3 10) chain E residue 222 type sequence N description binding site for residue SO4 E 302 source : AD3 11) chain E residue 43 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ source Swiss-Prot : SWS_FT_FI4 12) chain E residue 203 type BINDING sequence S description in other chain => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ source Swiss-Prot : SWS_FT_FI5 13) chain E residue 179 type BINDING sequence E description in other chain => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ source Swiss-Prot : SWS_FT_FI5 14) chain E residue 20 type catalytic sequence G description 375 source MCSA : MCSA5 15) chain E residue 24 type catalytic sequence R description 375 source MCSA : MCSA5 16) chain E residue 43 type catalytic sequence R description 375 source MCSA : MCSA5 17) chain E residue 87 type catalytic sequence R description 375 source MCSA : MCSA5 18) chain E residue 90 type catalytic sequence S description 375 source MCSA : MCSA5 19) chain E residue 204 type catalytic sequence A description 375 source MCSA : MCSA5 20) chain E residue 217 type catalytic sequence A description 375 source MCSA : MCSA5 21) chain E residue 204 type ACT_SITE sequence A description Proton donor => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:30337572 source Swiss-Prot : SWS_FT_FI1 22) chain E residue 217 type SITE sequence A description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572 source Swiss-Prot : SWS_FT_FI6 23) chain E residue 26 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI7 24) chain E residue 4 type BINDING sequence H description BINDING => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ source Swiss-Prot : SWS_FT_FI2 25) chain E residue 20 type BINDING sequence G description in other chain => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ source Swiss-Prot : SWS_FT_FI3 26) chain E residue 24 type BINDING sequence R description in other chain => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ source Swiss-Prot : SWS_FT_FI3 27) chain E residue 87 type BINDING sequence R description in other chain => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ source Swiss-Prot : SWS_FT_FI3

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