eF-site ID 4tn3-AB PDB Code 4tn3 Chain A, B click to enlarge Title Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha Classification ANTIVIRAL PROTEIN Compound TRIM5/cyclophilin A fusion protein/T4 Lysozyme chimera Source (ENLYS_BPT4) Sequence A:  VDHCARHGEKLLLFCQEDSKVICWLCKDSQEHRGHHTFLM EEVAQEYHVKLQTALEMLRQKQQEAEKLEADIREEKASWK IQIDYDKTNVSADFEQLREILDWEESNELQNLEKEEEDIL KSLTKSETEMVQQTQYMRELISELEHRLQMMDLLQGVDGI IKRIENMTLFRAPDLKGMLDMFRDAAAEESPVLLAMNIFE MLRIDEGLRLKIYKNTEGYYTIGIGHLLTKSPSLNAAKSE LDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLK PVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKR WDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL B:  PGPEEGQKVDHCARHGEKLLLFCQEDSKVICWLCKDSQEH RGHHTFLMEEVAQEYHVKLQTALEMLRQKQQEAEKLEADI REEKASWKIQIDYDKTNVSADFEQLREILDWEESNELQNL EKEEEDILKSLTKSETEMVQQTQYMRELISELEHRLQGSM MDLLQGVDGIIKRIENMTLKKPKTFHKNQRRVFRAPDLMN IFEMLRIDEGLRLKIYKNTEGYYTIGIGHLLTKSPSLNAA KSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNA KLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQ QKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYK NL Description Functional site 1) chain A residue 108 type sequence C description binding site for residue ZN A 701 source : AC1 2) chain A residue 111 type sequence D description binding site for residue ZN A 701 source : AC1 3) chain A residue 124 type sequence E description binding site for residue ZN A 701 source : AC1 4) chain A residue 125 type sequence H description binding site for residue ZN A 701 source : AC1 5) chain A residue 128 type sequence H description binding site for residue ZN A 701 source : AC1 6) chain A residue 97 type sequence C description binding site for residue ZN A 702 source : AC2 7) chain A residue 100 type sequence H description binding site for residue ZN A 702 source : AC2 8) chain A residue 116 type sequence C description binding site for residue ZN A 702 source : AC2 9) chain A residue 119 type sequence C description binding site for residue ZN A 702 source : AC2 10) chain B residue 108 type sequence C description binding site for residue ZN B 700 source : AC3 11) chain B residue 111 type sequence D description binding site for residue ZN B 700 source : AC3 12) chain B residue 125 type sequence H description binding site for residue ZN B 700 source : AC3 13) chain B residue 128 type sequence H description binding site for residue ZN B 700 source : AC3 14) chain B residue 97 type sequence C description binding site for residue ZN B 701 source : AC4 15) chain B residue 100 type sequence H description binding site for residue ZN B 701 source : AC4 16) chain B residue 116 type sequence C description binding site for residue ZN B 701 source : AC4 17) chain B residue 119 type sequence C description binding site for residue ZN B 701 source : AC4 18) chain A residue 314 type catalytic sequence E description 921 source MCSA : MCSA1 19) chain A residue 323 type catalytic sequence N description 921 source MCSA : MCSA1 20) chain B residue 314 type catalytic sequence E description 921 source MCSA : MCSA2 21) chain B residue 323 type catalytic sequence N description 921 source MCSA : MCSA2 22) chain A residue 314 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 314 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 323 type ACT_SITE sequence N description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 323 type ACT_SITE sequence N description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 335 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 407 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 335 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 407 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 420 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 31) chain A residue 435 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 32) chain B residue 420 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 33) chain B residue 435 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4

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