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Functional site
| 1) | chain | A |
| residue | 147 | |
| type | ACT_SITE | |
| sequence | D | |
| description | Proton acceptor | |
| source | Swiss-Prot : SWS_FT_FI1 | |
| 2) | chain | A |
| residue | 27 | |
| type | MOD_RES | |
| sequence | S | |
| description | Phosphoserine; by SGK1 => ECO:0000250|UniProtKB:P28482 | |
| source | Swiss-Prot : SWS_FT_FI4 | |
| 3) | chain | A |
| residue | 29-53 | |
| type | prosite | |
| sequence | IGEGAYGMVCSAYDNLNKVRVAIKK | |
| description | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGMVCsAydnlnkvrv.........AIKK | |
| source | prosite : PS00107 | |
| 4) | chain | A |
| residue | 143-155 | |
| type | prosite | |
| sequence | VLHRDLKPSNLLL | |
| description | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpsNLLL | |
| source | prosite : PS00108 | |
| 5) | chain | A |
| residue | 57-159 | |
| type | prosite | |
| sequence |
FEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQM KDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLK YIHSANVLHRDLKPSNLLLNTTC |
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| description | MAPK MAP kinase signature. FehqtycqrtlREikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrglkyihsanvlh..........RDlKpsnlllnttC | |
| source | prosite : PS01351 | |
| 6) | chain | A |
| residue | 183 | |
| type | MOD_RES | |
| sequence | T | |
| description | Phosphothreonine => ECO:0007744|PubMed:22673903 | |
| source | Swiss-Prot : SWS_FT_FI5 | |
| 7) | chain | A |
| residue | 185 | |
| type | MOD_RES | |
| sequence | Y | |
| description | Phosphotyrosine => ECO:0007744|PubMed:22673903 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 8) | chain | A |
| residue | 188 | |
| type | MOD_RES | |
| sequence | T | |
| description | Phosphothreonine; by autocatalysis => ECO:0000250|UniProtKB:P28482 | |
| source | Swiss-Prot : SWS_FT_FI7 | |
| 9) | chain | A |
| residue | 246 | |
| type | MOD_RES | |
| sequence | S | |
| description | Phosphoserine => ECO:0000250|UniProtKB:P28482 | |
| source | Swiss-Prot : SWS_FT_FI8 | |
| 10) | chain | A |
| residue | 282 | |
| type | MOD_RES | |
| sequence | S | |
| description | Phosphoserine => ECO:0000250|UniProtKB:P28482 | |
| source | Swiss-Prot : SWS_FT_FI8 | |
| 11) | chain | A |
| residue | 244 | |
| type | MOD_RES | |
| sequence | S | |
| description | Phosphoserine => ECO:0000250|UniProtKB:P28482 | |
| source | Swiss-Prot : SWS_FT_FI8 | |
| 12) | chain | A |
| residue | 52 | |
| type | BINDING | |
| sequence | K | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:8639522 | |
| source | Swiss-Prot : SWS_FT_FI2 | |
| 13) | chain | A |
| residue | 29 | |
| type | BINDING | |
| sequence | I | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:8639522 | |
| source | Swiss-Prot : SWS_FT_FI2 | |