eF-site ID 4s2e-AB PDB Code 4s2e Chain A, B click to enlarge Title Phosphate ion bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 Classification TRANSFERASE Compound Thymidylate kinase Source Aquifex aeolicus (strain VF5) (KTHY_AQUAE) Sequence A:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALS B:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALSGVL Description Functional site 1) chain A residue 10 type sequence G description BINDING SITE FOR RESIDUE PO4 A 201 source : AC1 2) chain A residue 11 type sequence S description BINDING SITE FOR RESIDUE PO4 A 201 source : AC1 3) chain A residue 12 type sequence G description BINDING SITE FOR RESIDUE PO4 A 201 source : AC1 4) chain A residue 13 type sequence K description BINDING SITE FOR RESIDUE PO4 A 201 source : AC1 5) chain A residue 14 type sequence T description BINDING SITE FOR RESIDUE PO4 A 201 source : AC1 6) chain B residue 8 type sequence I description BINDING SITE FOR RESIDUE PO4 B 201 source : AC2 7) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE PO4 B 201 source : AC2 8) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE PO4 B 201 source : AC2 9) chain B residue 12 type sequence G description BINDING SITE FOR RESIDUE PO4 B 201 source : AC2 10) chain B residue 13 type sequence K description BINDING SITE FOR RESIDUE PO4 B 201 source : AC2 11) chain B residue 14 type sequence T description BINDING SITE FOR RESIDUE PO4 B 201 source : AC2 12) chain A residue 87-99 type prosite sequence ILDRFVLSTIAYQ description THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRFvlSTiAYQ source prosite : PS01331 13) chain A residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1

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