eF-site ID 4s22-ABCD PDB Code 4s22 Chain A, B, C, D click to enlarge Title Crystal structure of K29 linked di-Ubiquitin Classification HYDROLASE Compound Ubiquitin Source ORGANISM_COMMON: bovine,cow,domestic cattle,domestic cow; ORGANISM_SCIENTIFIC: Bos taurus; Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL D:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain A residue 65 type sequence S description BINDING SITE FOR RESIDUE IOD A 101 source : AC1 2) chain A residue 73 type sequence L description BINDING SITE FOR RESIDUE IOD A 102 source : AC2 3) chain B residue 71 type sequence L description BINDING SITE FOR RESIDUE IOD B 101 source : AC3 4) chain B residue 47 type sequence G description BINDING SITE FOR RESIDUE IOD B 102 source : AC4 5) chain B residue 46 type sequence A description BINDING SITE FOR RESIDUE EDO B 103 source : AC5 6) chain B residue 48 type sequence K description BINDING SITE FOR RESIDUE EDO B 103 source : AC5 7) chain D residue 16 type sequence E description BINDING SITE FOR RESIDUE IOD D 101 source : AC6 8) chain D residue 46 type sequence A description BINDING SITE FOR RESIDUE GOL D 102 source : AC7 9) chain D residue 48 type sequence K description BINDING SITE FOR RESIDUE GOL D 102 source : AC7 10) chain D residue 74 type sequence R description BINDING SITE FOR RESIDUE GOL D 102 source : AC7 11) chain A residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI3 13) chain C residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI3 14) chain D residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI4 16) chain D residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI4 17) chain A residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 18) chain A residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 19) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 20) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 21) chain C residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 22) chain C residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 23) chain D residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 24) chain D residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 25) chain A residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 26) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 27) chain C residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 28) chain D residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 29) chain B residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI6 30) chain D residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI6 31) chain A residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 32) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 33) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 34) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 35) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 36) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 37) chain C residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 38) chain C residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 39) chain C residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 40) chain C residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 41) chain C residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 42) chain A residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 43) chain C residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 44) chain C residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 45) chain D residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 46) chain D residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 47) chain D residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 48) chain D residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 49) chain D residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 50) chain D residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 51) chain D residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 52) chain A residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 53) chain A residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 54) chain A residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 55) chain A residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 56) chain A residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 57) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 58) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62987 source Swiss-Prot : SWS_FT_FI5 59) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299

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