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Title
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Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core |
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Classification
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VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR |
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Compound
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clade A/E 93TH057 HIV-1 gp120 core |
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Source
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(4S1R) |
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Sequence
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G: |
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQE
IHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLT
GGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGT
GPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSEN
LTNNAKTIIVHLNKSVEINCTRPSNDIRKAYCEINGTKWN
KVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRG
EFFYCNTTQLFNNTCIGKGCNGTITLPCKIKQIINMWQGT
GQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRP
GGGNIKDNWRSELYKYKVVQIE
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| H: |
QVRLVQSGPQIKTPGASVTISCGTSGYDFMESLINWVRQD
IGKGPEWMGWINPRGGGVNYGRRFQGKVTMTRDVSSGTAY
LTLRGLTSDDTAKYYCVRGKSCCGGRRYCNGADCFNWDFE
HWGQGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCL
VKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV
VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
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| L: |
VLTQSPGTLSLSPGETAIISCRTSQYGSLAWYQQRPGQAP
RLVIYSGSTRAAGIPDRFSGSRWGPDYTLTISNLESGDFG
VYYCQQYEFFGQGTKVQVDIKRTVAAPSVFIFPPSDEQLK
VVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS
TYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
GEC
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Description
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