eF-site ID 4s0v-A
PDB Code 4s0v
Chain A

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Title Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant
Classification SIGNALING PROTEIN
Compound Human Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase
Source Homo sapiens (Human) (OX2R_HUMAN)
Sequence A:  PKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVT
NYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKV
IPYLQTVSVSVSVLTLSCIALDRWYAICHPSTAKRARNSI
VIIWIVSCIIMIPQAIVMECSTVFKTTLFTVCDERWGGEI
YPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQGIDC
SFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRG
QKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWAR
SLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPF
GLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPG
ELANAILKALELSRSDLSKFRENCKKRAMSFSKQIRARRK
TARMLMVVLLVFAICYLPISILNVLKRVFGMFAHDRETVY
AWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSC
Description


Functional site

1) chain A
residue 111
type
sequence T
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

2) chain A
residue 114
type
sequence V
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

3) chain A
residue 120
type
sequence W
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

4) chain A
residue 130
type
sequence I
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

5) chain A
residue 131
type
sequence P
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

6) chain A
residue 134
type
sequence Q
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

7) chain A
residue 135
type
sequence T
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

8) chain A
residue 187
type
sequence Q
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

9) chain A
residue 212
type
sequence E
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

10) chain A
residue 320
type
sequence I
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

11) chain A
residue 324
type
sequence N
description BINDING SITE FOR RESIDUE SUV A 2001
source : AC1

12) chain A
residue 140-156
type prosite
sequence VSVLTLSCIALDRWYAI
description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSVlTLSCIALDRWYaI
source prosite : PS00237

13) chain A
residue 55-75
type TRANSMEM
sequence WVLIAGYIIVFVVALIGNVLV
description Helical; Name=1 => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 324
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:25533960, ECO:0007744|PDB:4S0V
source Swiss-Prot : SWS_FT_FI10

15) chain A
residue 76-88
type TOPO_DOM
sequence CVAVWKNHHMRTV
description Cytoplasmic => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 151-170
type TOPO_DOM
sequence DRWYAICHPSTAKRAR
description Cytoplasmic => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 89-110
type TRANSMEM
sequence TNYFIVNLSLADVLVTITCLPA
description Helical; Name=2 => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI3

18) chain A
residue 111-127
type TOPO_DOM
sequence TLVVDITETWFFGQSLC
description Extracellular => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI4

19) chain A
residue 192-222
type TOPO_DOM
sequence ECSTVFKTTLFTVCDERWGGEIYPKM
description Extracellular => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI4

20) chain A
residue 327-342
type TOPO_DOM
sequence KRVFGMFAHDRETV
description Extracellular => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI4

21) chain A
residue 128-150
type TRANSMEM
sequence KVIPYLQTVSVSVSVLTLSCIAL
description Helical; Name=3 => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI5

22) chain A
residue 171-191
type TRANSMEM
sequence NSIVIIWIVSCIIMIPQAIVM
description Helical; Name=4 => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI6

23) chain A
residue 223-243
type TRANSMEM
sequence YHICFFLVTYMAPLCLMVLAY
description Helical; Name=5 => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI7

24) chain A
residue 305-326
type TRANSMEM
sequence MLMVVLLVFAICYLPISILNVL
description Helical; Name=6 => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI8

25) chain A
residue 343-366
type TRANSMEM
sequence YAWFTFSHWLVYANSAANPIIYNF
description Helical; Name=7 => ECO:0000269|PubMed:25533960
source Swiss-Prot : SWS_FT_FI9


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