eF-site ID 4s0v-A PDB Code 4s0v Chain A click to enlarge Title Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant Classification SIGNALING PROTEIN Compound Human Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase Source Homo sapiens (Human) (OX2R_HUMAN) Sequence A:  PKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVT NYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKV IPYLQTVSVSVSVLTLSCIALDRWYAICHPSTAKRARNSI VIIWIVSCIIMIPQAIVMECSTVFKTTLFTVCDERWGGEI YPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQGIDC SFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRG QKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWAR SLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPF GLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPG ELANAILKALELSRSDLSKFRENCKKRAMSFSKQIRARRK TARMLMVVLLVFAICYLPISILNVLKRVFGMFAHDRETVY AWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSC Description Functional site 1) chain A residue 111 type sequence T description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 2) chain A residue 114 type sequence V description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 3) chain A residue 120 type sequence W description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 4) chain A residue 130 type sequence I description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 5) chain A residue 131 type sequence P description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 6) chain A residue 134 type sequence Q description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 7) chain A residue 135 type sequence T description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 8) chain A residue 187 type sequence Q description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 9) chain A residue 212 type sequence E description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 10) chain A residue 320 type sequence I description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 11) chain A residue 324 type sequence N description BINDING SITE FOR RESIDUE SUV A 2001 source : AC1 12) chain A residue 140-156 type prosite sequence VSVLTLSCIALDRWYAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSVlTLSCIALDRWYaI source prosite : PS00237 13) chain A residue 55-75 type TRANSMEM sequence WVLIAGYIIVFVVALIGNVLV description Helical; Name=1 => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 324 type BINDING sequence N description BINDING => ECO:0000269|PubMed:25533960, ECO:0007744|PDB:4S0V source Swiss-Prot : SWS_FT_FI10 15) chain A residue 76-88 type TOPO_DOM sequence CVAVWKNHHMRTV description Cytoplasmic => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 151-170 type TOPO_DOM sequence DRWYAICHPSTAKRAR description Cytoplasmic => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 89-110 type TRANSMEM sequence TNYFIVNLSLADVLVTITCLPA description Helical; Name=2 => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 111-127 type TOPO_DOM sequence TLVVDITETWFFGQSLC description Extracellular => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 192-222 type TOPO_DOM sequence ECSTVFKTTLFTVCDERWGGEIYPKM description Extracellular => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI4 20) chain A residue 327-342 type TOPO_DOM sequence KRVFGMFAHDRETV description Extracellular => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 128-150 type TRANSMEM sequence KVIPYLQTVSVSVSVLTLSCIAL description Helical; Name=3 => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI5 22) chain A residue 171-191 type TRANSMEM sequence NSIVIIWIVSCIIMIPQAIVM description Helical; Name=4 => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI6 23) chain A residue 223-243 type TRANSMEM sequence YHICFFLVTYMAPLCLMVLAY description Helical; Name=5 => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI7 24) chain A residue 305-326 type TRANSMEM sequence MLMVVLLVFAICYLPISILNVL description Helical; Name=6 => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI8 25) chain A residue 343-366 type TRANSMEM sequence YAWFTFSHWLVYANSAANPIIYNF description Helical; Name=7 => ECO:0000269|PubMed:25533960 source Swiss-Prot : SWS_FT_FI9

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