eF-site ID 4rzs-ABCD PDB Code 4rzs Chain A, B, C, D click to enlarge Title Lac repressor engineered to bind sucralose, unliganded tetramer Classification TRANSCRIPTION Compound Lac repressor Source (C9QQT3_ECOD1) Sequence A:  PVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAM AELNYIPNRSLLIGVATSSLALHAPSQIVAAIKSRADQLG ASVVVSMVERSGVEACKAAVHNLLAQRVSGLIINYPLDDQ DAIAVEAACTNVPALFLTASDQTPLNSIIFSHEDGTRLGV EHLVALGHQQIALLAGPLSSVDARLRLAGWHKYLTRNQIQ PIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMAL GAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQ DFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLA PNTQTASPRALADSLMQLARQVSRLES B:  PVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAM AELNYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAA IKSRADQLGASVVVSMVERSGVEACKAAVHNLLAQRVSGL IINYPLDDQDAIAVEAACTNVPALFLTASDQTPLNSIIFS HEDGTRLGVEHLVALGHQQIALLAGPLSSVDARLRLAGWH KYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAM LVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCY IPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVS LVKRKTTLAPNTQTASPRALADSLMQLARQVSRLE C:  SLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVE RSGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAAC TNVPALFLTASDQTPLNSIIFSHEDGTRLGVEHLVALGHQ QIALLAGPLSSVDARLRLAGWHKYLTRNQIQPIAEREGDW SAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITES GLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTS VDRLLQLSQGQAVKGNQLLPVSLVKRKTTLAPNTQTASPR ALADSLMQLARQVSRLES D:  SLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVE RSGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAAC TNVPALFLTASDQTPLNSIIFSHEDGTRLGVEHLVALGHQ QIALLAGPLSSVDARLRLAGWHKYLTRNQIQPIAEREGDW SAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITES GLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTS VDRLLQLSQGQAVKGNQLLPVSLVKRKTTLAPNTQTASPR ALADSLMQLARQVSRL Description Functional site 1) chain A residue 197 type sequence R description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 2) chain A residue 246 type sequence N description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 3) chain A residue 274 type sequence D description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 4) chain A residue 291 type sequence Q description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 5) chain B residue 197 type sequence R description BINDING SITE FOR RESIDUE GOL B 501 source : AC2 6) chain B residue 246 type sequence N description BINDING SITE FOR RESIDUE GOL B 501 source : AC2 7) chain B residue 274 type sequence D description BINDING SITE FOR RESIDUE GOL B 501 source : AC2 8) chain B residue 291 type sequence Q description BINDING SITE FOR RESIDUE GOL B 501 source : AC2 9) chain C residue 193 type sequence D description BINDING SITE FOR RESIDUE GOL C 501 source : AC3 10) chain C residue 197 type sequence R description BINDING SITE FOR RESIDUE GOL C 501 source : AC3 11) chain C residue 246 type sequence N description BINDING SITE FOR RESIDUE GOL C 501 source : AC3 12) chain C residue 274 type sequence D description BINDING SITE FOR RESIDUE GOL C 501 source : AC3 13) chain D residue 193 type sequence D description BINDING SITE FOR RESIDUE GOL D 501 source : AC4 14) chain D residue 197 type sequence R description BINDING SITE FOR RESIDUE GOL D 501 source : AC4 15) chain D residue 274 type sequence D description BINDING SITE FOR RESIDUE GOL D 501 source : AC4 16) chain D residue 291 type sequence Q description BINDING SITE FOR RESIDUE GOL D 501 source : AC4 17) chain A residue 6-24 type prosite sequence LYDVAEYAGVSYQTVSRVV description HTH_LACI_1 LacI-type HTH domain signature. LyDVAeyAgVSyqTVsrVV source prosite : PS00356 18) chain A residue 6-25 type DNA_BIND sequence LYDVAEYAGVSYQTVSRVVN description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00111 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 6-25 type DNA_BIND sequence LYDVAEYAGVSYQTVSRVVN description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00111 source Swiss-Prot : SWS_FT_FI1

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