eF-site ID 4rzr-AD PDB Code 4rzr Chain A, D click to enlarge Title Bypass of a bulky adduct dG1,8 by DPO4 Classification TRANSFERASE/DNA Compound DNA polymerase IV Source Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (4RZR) Sequence A:  MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDS GAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEV YQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYRE AYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP NGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTR VRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRI PKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQ KILEEDERKIRRIGVRFSKFIE D:  MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDS GAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEV YQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYRE AYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP NGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTR VRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRI PKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQ KILEEDERKIRRIGVRFSKFIE Description Functional site 1) chain A residue 7 type sequence D description BINDING SITE FOR RESIDUE CA A 401 source : AC1 2) chain A residue 105 type sequence D description BINDING SITE FOR RESIDUE CA A 401 source : AC1 3) chain A residue 106 type sequence E description BINDING SITE FOR RESIDUE CA A 401 source : AC1 4) chain A residue 7 type sequence D description BINDING SITE FOR RESIDUE CA A 402 source : AC2 5) chain A residue 8 type sequence F description BINDING SITE FOR RESIDUE CA A 402 source : AC2 6) chain A residue 105 type sequence D description BINDING SITE FOR RESIDUE CA A 402 source : AC2 7) chain A residue 181 type sequence A description BINDING SITE FOR RESIDUE NA A 403 source : AC3 8) chain A residue 186 type sequence I description BINDING SITE FOR RESIDUE NA A 403 source : AC3 9) chain A residue 332 type sequence R description BINDING SITE FOR RESIDUE TRS B 101 source : AC4 10) chain D residue 7 type sequence D description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 11) chain D residue 8 type sequence F description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 12) chain D residue 9 type sequence D description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 13) chain D residue 10 type sequence Y description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 14) chain D residue 11 type sequence F description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 15) chain D residue 12 type sequence Y description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 16) chain D residue 44 type sequence A description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 17) chain D residue 45 type sequence T description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 18) chain D residue 48 type sequence Y description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 19) chain D residue 51 type sequence R description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 20) chain D residue 105 type sequence D description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 21) chain D residue 159 type sequence K description BINDING SITE FOR RESIDUE DCP D 401 source : AC5 22) chain D residue 7 type sequence D description BINDING SITE FOR RESIDUE CA D 402 source : AC6 23) chain D residue 8 type sequence F description BINDING SITE FOR RESIDUE CA D 402 source : AC6 24) chain D residue 105 type sequence D description BINDING SITE FOR RESIDUE CA D 402 source : AC6 25) chain D residue 7 type sequence D description BINDING SITE FOR RESIDUE CA D 403 source : AC7 26) chain D residue 105 type sequence D description BINDING SITE FOR RESIDUE CA D 403 source : AC7 27) chain D residue 106 type sequence E description BINDING SITE FOR RESIDUE CA D 403 source : AC7 28) chain D residue 181 type sequence A description BINDING SITE FOR RESIDUE NA D 404 source : AC8 29) chain D residue 186 type sequence I description BINDING SITE FOR RESIDUE NA D 404 source : AC8 30) chain D residue 80 type sequence V description BINDING SITE FOR RESIDUE GOL D 405 source : AC9 31) chain D residue 83 type sequence Q description BINDING SITE FOR RESIDUE GOL D 405 source : AC9 32) chain D residue 84 type sequence V description BINDING SITE FOR RESIDUE GOL D 405 source : AC9 33) chain D residue 87 type sequence R description BINDING SITE FOR RESIDUE GOL D 405 source : AC9 34) chain D residue 100 type sequence E description BINDING SITE FOR RESIDUE GOL D 406 source : BC1 35) chain D residue 148 type sequence K description BINDING SITE FOR RESIDUE GOL D 406 source : BC1 36) chain D residue 233 type sequence Y description BINDING SITE FOR RESIDUE GOL D 406 source : BC1 37) chain D residue 240 type sequence R description BINDING SITE FOR RESIDUE GOL D 406 source : BC1 38) chain D residue 106 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 39) chain A residue 106 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 40) chain D residue 7 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 41) chain D residue 105 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 42) chain A residue 7 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 43) chain A residue 105 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 44) chain D residue 12 type SITE sequence Y description Substrate discrimination source Swiss-Prot : SWS_FT_FI3 45) chain A residue 12 type SITE sequence Y description Substrate discrimination source Swiss-Prot : SWS_FT_FI3

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