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Title
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Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC134 in complex with HIV-1 clade A Q842.d12 gp120 |
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Classification
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VIRAL PROTEIN/IMMUNE SYSTEM |
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Compound
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HIV-1 Clade A Q842.d12 gp120 |
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Source
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(4RX4) |
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Sequence
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A: |
GQLVQSGGGVKKPGTSVTISCLASEYTFNEFVIHWIRQAP
GQGPVWLGLIKRSGRLMTSYKFQDRLSLRRDRSTGTVFME
LRGLRLDDTAVYYCARDGLGEVAPAYLYGIDAWGQGSTVI
VTSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNS
GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC
NVNHKPSNTKVDKKAEPKSCDK
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| D: |
EIVLTQSPATLSLSPGERATLSCRASQGLNFVVWYQQKGG
QAPRLLIHGPTDRAPGVPDRFSARGSGTEFSLVISSVEPD
DFALYYCQEYSSTPYNFGPGTRVERKRTVAAPSVFIFPPS
DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE
SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL
RSPVTKSFNRGEC
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| E: |
VWKEAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQE
IHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLT
CPKVTFEPIPIHYCAPAGFAILKCKDEEFNGIGPCKNVST
VQCTHGIKPVVSTQLLLNGSLAEKEVKIRCENITNNAKTI
IVQLVNPVKINCTRPNNDIRQAHCNVNRTEWNNTLHQVVE
QLRKHFNKTINFANSTGGDLEITTHSFNCGGEFFYCNTTN
LFNSTTIILPCRIKQIINMWQRVGQAMYAPPIRGVIRCES
NITGLILTRDSTRETFRPGGGDMRDNWRSELYKYKVVKIE
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| G: |
WKEAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEI
HLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTA
CPKVTFEPIPIHYCAPAGFAILKCKDEEFNGIGPCKNVST
VQCTHGIKPVVSTQLLLNGSLAEKEVKIRCENITNNAKTI
IVQLVNPVKINCTRPDIRQAHCNVNRTEWNNTLHQVVEQL
RKHFNKTINFANSTGGDLEITTHSFNCGGEFFYCNTTNLF
NSTWNTIILPCRIKQIINMWQRVGQAMYAPPIRGVIRCES
NITGLILTRDGGNTNSTRETFRPGGGDMRDNWRSELYKYK
VVKIE
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| H: |
GQLVQSGGGVKKPGTSVTISCLASEYTFNEFVIHWIRQAP
GQGPVWLGLIKRSGRLMTSYKFQDRLSLRRDRSTGTVFME
LRGLRLDDTAVYYCARDGLGEVAPAYLYGIDAWGQGSTVI
VTSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNS
GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC
NVNHKPSNTKVDKKAEP
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| L: |
IVLTQSPATLSLSPGERATLSCRASQGLNFVVWYQQKGGQ
APRLLIHGPTDRAPGVPDRFSARGSGTEFSLVISSVEPDD
FALYYCQEYSSTPYNFGPGTRVERKRTVAAPSVFIFPPSD
EQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQES
VTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLR
SPVTKSFNRGEC
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Description
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(1) |
HIV-1 Clade A Q842.d12 gp120, 8ANC134 Heavy chain, 8ANC134 Light Chain
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