eF-site ID 4rwv-AB PDB Code 4rwv Chain A, B click to enlarge Title Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution Classification TRANSCRIPTION Compound Nuclear receptor subfamily 5 group A member 2 Source Homo sapiens (Human) (F1D8P4_HUMAN) Sequence A:  SPASIPHLILELLKXEPDEPQVQAKIMAYLQQEQANRSKH EKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMK LLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSII ASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVL FSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKF GQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEML HAK B:  PRQGSILYSLLTSSK Description Functional site 1) chain A residue 342 type sequence F description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 2) chain A residue 416 type sequence I description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 3) chain A residue 419 type sequence Q description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 4) chain A residue 420 type sequence A description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 5) chain A residue 421 type sequence G description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 6) chain A residue 422 type sequence A description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 7) chain A residue 423 type sequence T description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 8) chain A residue 424 type sequence L description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 9) chain A residue 513 type sequence A description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 10) chain A residue 516 type sequence Y description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 11) chain A residue 520 type sequence K description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 12) chain A residue 537 type sequence H description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 13) chain B residue 140 type sequence P description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 14) chain B residue 141 type sequence R description BINDING SITE FOR RESIDUE PIZ A 601 source : AC1 15) chain A residue 323 type sequence M description BINDING SITE FOR RESIDUE EDO A 602 source : AC2 16) chain A residue 326 type sequence L description BINDING SITE FOR RESIDUE EDO A 602 source : AC2 17) chain A residue 409 type sequence Q description BINDING SITE FOR RESIDUE EDO A 602 source : AC2 18) chain A residue 518 type sequence Y description BINDING SITE FOR RESIDUE EDO A 602 source : AC2 19) chain A residue 519 type sequence Y description BINDING SITE FOR RESIDUE EDO A 602 source : AC2 20) chain A residue 522 type sequence L description BINDING SITE FOR RESIDUE EDO A 602 source : AC2 21) chain A residue 426 type sequence N description BINDING SITE FOR RESIDUE EDO A 603 source : AC3 22) chain A residue 430 type sequence H description BINDING SITE FOR RESIDUE EDO A 603 source : AC3 23) chain A residue 508 type sequence A description BINDING SITE FOR RESIDUE EDO A 603 source : AC3 24) chain A residue 512 type sequence Q description BINDING SITE FOR RESIDUE EDO A 603 source : AC3 25) chain A residue 298 type sequence P description BINDING SITE FOR RESIDUE EDO A 604 source : AC4 26) chain A residue 444 type sequence D description BINDING SITE FOR RESIDUE EDO A 604 source : AC4 27) chain A residue 446 type sequence R description BINDING SITE FOR RESIDUE EDO A 604 source : AC4 28) chain A residue 489 type sequence Y description BINDING SITE FOR RESIDUE EDO A 604 source : AC4 29) chain A residue 370 type sequence K description BINDING SITE FOR RESIDUE EDO A 605 source : AC5 30) chain A residue 372 type sequence D description BINDING SITE FOR RESIDUE EDO A 605 source : AC5 31) chain A residue 429 type sequence S description BINDING SITE FOR RESIDUE EDO A 605 source : AC5 32) chain A residue 430 type sequence H description BINDING SITE FOR RESIDUE EDO A 605 source : AC5 33) chain A residue 474 type sequence Q description BINDING SITE FOR RESIDUE EDO A 606 source : AC6 34) chain A residue 478 type sequence N description BINDING SITE FOR RESIDUE EDO A 606 source : AC6 35) chain A residue 503 type sequence L description BINDING SITE FOR RESIDUE EDO A 606 source : AC6 36) chain B residue 140 type sequence P description BINDING SITE FOR RESIDUE TRS B 201 source : AC7 37) chain B residue 141 type sequence R description BINDING SITE FOR RESIDUE TRS B 201 source : AC7 38) chain B residue 142 type sequence Q description BINDING SITE FOR RESIDUE TRS B 201 source : AC7 39) chain B residue 144 type sequence S description BINDING SITE FOR RESIDUE TRS B 201 source : AC7 40) chain B residue 147 type sequence Y description BINDING SITE FOR RESIDUE TRS B 201 source : AC7 41) chain A residue 379-399 type ZN_FING sequence QNCWSELLILDHIYRQVVHGK description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 415-439 type ZN_FING sequence IIASQAGATLNNLMSHAQELVAKLR description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 376-447 type DNA_BIND sequence KLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSI IASQAGATLNNLMSHAQELVAKLRSLQFDQRE description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links