eF-site ID 4rwp-ABC PDB Code 4rwp Chain A, B, C click to enlarge Title Crystal structure of porcine OAS1 in complex with dsRNA Classification TRANSFERASE/RNA Compound 2'-5'-oligoadenylate synthase 1 Source Sus scrofa (Pig) (4RWP) Sequence A:  MELRHTPARDLDKFIEDHLLPNTCFRTQVKEAIDIVCRFL KERCFQGTADPVRVSKVVKGGSSGKGTTLRGRSDADLVVF LTKLTSFEDQLRRRGEFIQEIRRQLEACQREQKFKVTFEV QSPRRENPRALSFVLSSPQLQQEVEFDVLPAFDALGQWTP GYKPNPEIYVQLIKECKSRGKEGEFSTCFTELQRDFLRNR PTKLKSLIRLVKHWYQTCKKTHGNKLPPQYALELLTVYAW EQGSRKTDFSTAQGFQTVLELVLKHQKLCIFWEAYYDFTN PVVGRCMLQQLKKPRPVILDPADPTGNVGGGDTHSWQRLA QEARVWLGYPCCKNLDGSLVGAWTML B:  GGCUUUUGACCUUUAUGAA C:  UCAUAAAGGUCAAAAGCC Description Functional site 1) chain A residue 157 type SITE sequence Q description Interaction with dsRNA => ECO:0000250|UniProtKB:P00973 source Swiss-Prot : SWS_FT_FI4 2) chain A residue 147 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P00973 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 229 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P00973 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 62 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P00973 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 74 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P00973 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 76 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P00973 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 209 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18604630 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 212 type BINDING sequence K description BINDING => ECO:0000305|PubMed:14636576 source Swiss-Prot : SWS_FT_FI3 9) chain A residue 61-80 type prosite sequence GSSGKGTTLRGRSDADLVVF description 25A_SYNTH_1 2'-5'-oligoadenylate synthases signature 1. GSsGKgTtLRgrsDaDLVvF source prosite : PS00832 10) chain A residue 295-305 type prosite sequence RPVILDPADPT description 25A_SYNTH_2 2'-5'-oligoadenylate synthases signature 2. RPVILDPaDPT source prosite : PS00833

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