eF-site ID 4rwd-AB
PDB Code 4rwd
Chain A, B

click to enlarge
Title XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide
Classification MEMBRANE PROTEIN
Compound Soluble cytochrome b562,Delta-type opioid receptor
Source (4RWD)
Sequence A:  ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDA
QKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYIQKYLGARSASSLALAIAI
TALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLA
LADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNM
FTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICI
WVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTV
TKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEK
DRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRR
DPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQL
C
B:  ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDA
QKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYIQKYLGARSASSLALAIAI
TALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLA
LADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNM
FTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICI
WVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTV
TKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEK
DRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRR
DPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQL
Description


Functional site

1) chain A
residue 50
type
sequence I
description BINDING SITE FOR RESIDUE OLA A 1201
source : AC1

2) chain A
residue 95
type
sequence D
description BINDING SITE FOR RESIDUE NA A 1202
source : AC2

3) chain A
residue 131
type
sequence N
description BINDING SITE FOR RESIDUE NA A 1202
source : AC2

4) chain A
residue 135
type
sequence S
description BINDING SITE FOR RESIDUE NA A 1202
source : AC2

5) chain A
residue 81
type
sequence K
description BINDING SITE FOR RESIDUE OLC A 1204
source : AC3

6) chain A
residue 86
type
sequence I
description BINDING SITE FOR RESIDUE OLC A 1204
source : AC3

7) chain A
residue 93
type
sequence L
description BINDING SITE FOR RESIDUE OLC A 1204
source : AC3

8) chain A
residue 169
type
sequence N
description BINDING SITE FOR RESIDUE OLC A 1204
source : AC3

9) chain A
residue 141
type
sequence M
description BINDING SITE FOR RESIDUE OLC A 1205
source : AC4

10) chain A
residue 168
type
sequence I
description BINDING SITE FOR RESIDUE OLC A 1205
source : AC4

11) chain A
residue 172
type
sequence I
description BINDING SITE FOR RESIDUE OLC A 1205
source : AC4

12) chain A
residue 175
type
sequence L
description BINDING SITE FOR RESIDUE OLC A 1205
source : AC4

13) chain A
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE OLA A 1206
source : AC5

14) chain A
residue 294
type
sequence P
description BINDING SITE FOR RESIDUE OLA A 1206
source : AC5

15) chain B
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE OLA B 1201
source : AC6

16) chain B
residue 95
type
sequence D
description BINDING SITE FOR RESIDUE NA B 1202
source : AC7

17) chain B
residue 131
type
sequence N
description BINDING SITE FOR RESIDUE NA B 1202
source : AC7

18) chain B
residue 135
type
sequence S
description BINDING SITE FOR RESIDUE NA B 1202
source : AC7

19) chain B
residue 48
type
sequence L
description BINDING SITE FOR RESIDUE OLA B 1204
source : AC8

20) chain B
residue 86
type
sequence I
description BINDING SITE FOR RESIDUE OLC B 1205
source : AC9

21) chain B
residue 89
type
sequence F
description BINDING SITE FOR RESIDUE OLC B 1205
source : AC9

22) chain B
residue 173
type
sequence W
description BINDING SITE FOR RESIDUE OLC B 1205
source : AC9

23) chain B
residue 128
type
sequence D
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

24) chain B
residue 129
type
sequence Y
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

25) chain B
residue 132
type
sequence M
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

26) chain B
residue 199
type
sequence M
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

27) chain B
residue 200
type
sequence L
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

28) chain B
residue 214
type
sequence K
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

29) chain B
residue 217
type
sequence V
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

30) chain B
residue 277
type
sequence I
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

31) chain B
residue 281
type
sequence V
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

32) chain B
residue 304
type
sequence I
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

33) chain B
residue 308
type
sequence Y
description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE
source : BC1

34) chain A
residue 128
type
sequence D
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

35) chain A
residue 129
type
sequence Y
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

36) chain A
residue 132
type
sequence M
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

37) chain A
residue 199
type
sequence M
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

38) chain A
residue 200
type
sequence L
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

39) chain A
residue 214
type
sequence K
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

40) chain A
residue 217
type
sequence V
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

41) chain A
residue 277
type
sequence I
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

42) chain A
residue 281
type
sequence V
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

43) chain A
residue 304
type
sequence I
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

44) chain A
residue 308
type
sequence Y
description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE
source : BC2

45) chain A
residue 111-122
type TOPO_DOM
sequence METWPFGELLCK
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

46) chain A
residue 187-206
type TOPO_DOM
sequence AVTRPRDGAVVCMLQFPSPS
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

47) chain A
residue 285-299
type TOPO_DOM
sequence TLVDIDRRDPLVVAA
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

48) chain B
residue 111-122
type TOPO_DOM
sequence METWPFGELLCK
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

49) chain B
residue 187-206
type TOPO_DOM
sequence AVTRPRDGAVVCMLQFPSPS
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

50) chain B
residue 285-299
type TOPO_DOM
sequence TLVDIDRRDPLVVAA
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

51) chain A
residue 123-144
type TRANSMEM
sequence AVLSIDYYNMFTSIFTLTMMSV
description Helical; Name=3 => ECO:0000250
source Swiss-Prot : SWS_FT_FI6

52) chain B
residue 123-144
type TRANSMEM
sequence AVLSIDYYNMFTSIFTLTMMSV
description Helical; Name=3 => ECO:0000250
source Swiss-Prot : SWS_FT_FI6

53) chain A
residue 164-186
type TRANSMEM
sequence KAKLINICIWVLASGVGVPIMVM
description Helical; Name=4 => ECO:0000250
source Swiss-Prot : SWS_FT_FI7

54) chain B
residue 164-186
type TRANSMEM
sequence KAKLINICIWVLASGVGVPIMVM
description Helical; Name=4 => ECO:0000250
source Swiss-Prot : SWS_FT_FI7

55) chain A
residue 207-238
type TRANSMEM
sequence WYWDTVTKICVFLFAFVVPILIITVCYGLMLL
description Helical; Name=5 => ECO:0000250
source Swiss-Prot : SWS_FT_FI8

56) chain B
residue 207-238
type TRANSMEM
sequence WYWDTVTKICVFLFAFVVPILIITVCYGLMLL
description Helical; Name=5 => ECO:0000250
source Swiss-Prot : SWS_FT_FI8

57) chain A
residue 262-284
type TRANSMEM
sequence MVLVVVGAFVVCWAPIHIFVIVW
description Helical; Name=6 => ECO:0000250
source Swiss-Prot : SWS_FT_FI9

58) chain B
residue 262-284
type TRANSMEM
sequence MVLVVVGAFVVCWAPIHIFVIVW
description Helical; Name=6 => ECO:0000250
source Swiss-Prot : SWS_FT_FI9

59) chain A
residue 134-150
type prosite
sequence TSIFTLTMMSVDRYIAV
description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMSVDRYIaV
source prosite : PS00237

60) chain A
residue 300-321
type TRANSMEM
sequence LHLCIALGYANSSLNPVLYAFL
description Helical; Name=7 => ECO:0000250
source Swiss-Prot : SWS_FT_FI10

61) chain B
residue 300-321
type TRANSMEM
sequence LHLCIALGYANSSLNPVLYAFL
description Helical; Name=7 => ECO:0000250
source Swiss-Prot : SWS_FT_FI10

62) chain A
residue 333
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11

63) chain A
residue 1007
type BINDING
sequence W
description axial binding residue
source Swiss-Prot : SWS_FT_FI1

64) chain A
residue 1102
type BINDING
sequence I
description axial binding residue
source Swiss-Prot : SWS_FT_FI1

65) chain B
residue 1007
type BINDING
sequence W
description axial binding residue
source Swiss-Prot : SWS_FT_FI1

66) chain B
residue 1102
type BINDING
sequence I
description axial binding residue
source Swiss-Prot : SWS_FT_FI1

67) chain A
residue 48-75
type TRANSMEM
sequence LAIAITALYSAVCAVGLLGNVLVMFGIV
description Helical; Name=1 => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

68) chain B
residue 48-75
type TRANSMEM
sequence LAIAITALYSAVCAVGLLGNVLVMFGIV
description Helical; Name=1 => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

69) chain A
residue 76-85
type TOPO_DOM
sequence RYTKMKTATN
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

70) chain A
residue 145-163
type TOPO_DOM
sequence DRYIAVCHPVKALDFRTPA
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

71) chain A
residue 239-261
type TOPO_DOM
sequence RLRSVRLLSGSKEKDRSLRRITR
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

72) chain B
residue 76-85
type TOPO_DOM
sequence RYTKMKTATN
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

73) chain B
residue 145-163
type TOPO_DOM
sequence DRYIAVCHPVKALDFRTPA
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

74) chain B
residue 239-261
type TOPO_DOM
sequence RLRSVRLLSGSKEKDRSLRRITR
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

75) chain A
residue 86-110
type TRANSMEM
sequence IYIFNLALADALATSTLPFQSAKYL
description Helical; Name=2 => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

76) chain B
residue 86-110
type TRANSMEM
sequence IYIFNLALADALATSTLPFQSAKYL
description Helical; Name=2 => ECO:0000250
source Swiss-Prot : SWS_FT_FI4


Display surface

Download
Links