eF-site ID 4rwd-A PDB Code 4rwd Chain A click to enlarge Title XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide Classification MEMBRANE PROTEIN Compound Soluble cytochrome b562,Delta-type opioid receptor Source (4RWD) Sequence A:  ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDA QKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN EGKVKEAQAAAEQLKTTRNAYIQKYLGARSASSLALAIAI TALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLA LADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNM FTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICI WVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTV TKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEK DRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRR DPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQL C Description Functional site 1) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE OLA A 1201 source : AC1 2) chain A residue 95 type sequence D description BINDING SITE FOR RESIDUE NA A 1202 source : AC2 3) chain A residue 131 type sequence N description BINDING SITE FOR RESIDUE NA A 1202 source : AC2 4) chain A residue 135 type sequence S description BINDING SITE FOR RESIDUE NA A 1202 source : AC2 5) chain A residue 81 type sequence K description BINDING SITE FOR RESIDUE OLC A 1204 source : AC3 6) chain A residue 86 type sequence I description BINDING SITE FOR RESIDUE OLC A 1204 source : AC3 7) chain A residue 93 type sequence L description BINDING SITE FOR RESIDUE OLC A 1204 source : AC3 8) chain A residue 169 type sequence N description BINDING SITE FOR RESIDUE OLC A 1204 source : AC3 9) chain A residue 141 type sequence M description BINDING SITE FOR RESIDUE OLC A 1205 source : AC4 10) chain A residue 168 type sequence I description BINDING SITE FOR RESIDUE OLC A 1205 source : AC4 11) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE OLC A 1205 source : AC4 12) chain A residue 175 type sequence L description BINDING SITE FOR RESIDUE OLC A 1205 source : AC4 13) chain A residue 44 type sequence S description BINDING SITE FOR RESIDUE OLA A 1206 source : AC5 14) chain A residue 294 type sequence P description BINDING SITE FOR RESIDUE OLA A 1206 source : AC5 15) chain A residue 128 type sequence D description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 16) chain A residue 129 type sequence Y description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 17) chain A residue 132 type sequence M description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 18) chain A residue 199 type sequence M description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 19) chain A residue 200 type sequence L description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 20) chain A residue 214 type sequence K description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 21) chain A residue 217 type sequence V description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 22) chain A residue 277 type sequence I description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 23) chain A residue 281 type sequence V description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 24) chain A residue 304 type sequence I description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 25) chain A residue 308 type sequence Y description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : BC2 26) chain A residue 111-122 type TOPO_DOM sequence METWPFGELLCK description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 27) chain A residue 187-206 type TOPO_DOM sequence AVTRPRDGAVVCMLQFPSPS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 28) chain A residue 285-299 type TOPO_DOM sequence TLVDIDRRDPLVVAA description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 29) chain A residue 123-144 type TRANSMEM sequence AVLSIDYYNMFTSIFTLTMMSV description Helical; Name=3 => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 30) chain A residue 164-186 type TRANSMEM sequence KAKLINICIWVLASGVGVPIMVM description Helical; Name=4 => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 31) chain A residue 207-238 type TRANSMEM sequence WYWDTVTKICVFLFAFVVPILIITVCYGLMLL description Helical; Name=5 => ECO:0000250 source Swiss-Prot : SWS_FT_FI8 32) chain A residue 262-284 type TRANSMEM sequence MVLVVVGAFVVCWAPIHIFVIVW description Helical; Name=6 => ECO:0000250 source Swiss-Prot : SWS_FT_FI9 33) chain A residue 134-150 type prosite sequence TSIFTLTMMSVDRYIAV description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMSVDRYIaV source prosite : PS00237 34) chain A residue 300-321 type TRANSMEM sequence LHLCIALGYANSSLNPVLYAFL description Helical; Name=7 => ECO:0000250 source Swiss-Prot : SWS_FT_FI10 35) chain A residue 333 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000255 source Swiss-Prot : SWS_FT_FI11 36) chain A residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI1 37) chain A residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI1 38) chain A residue 48-75 type TRANSMEM sequence LAIAITALYSAVCAVGLLGNVLVMFGIV description Helical; Name=1 => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 76-85 type TOPO_DOM sequence RYTKMKTATN description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 145-163 type TOPO_DOM sequence DRYIAVCHPVKALDFRTPA description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 41) chain A residue 239-261 type TOPO_DOM sequence RLRSVRLLSGSKEKDRSLRRITR description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 86-110 type TRANSMEM sequence IYIFNLALADALATSTLPFQSAKYL description Helical; Name=2 => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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