eF-site ID 4rwa-AB PDB Code 4rwa Chain A, B click to enlarge Title Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target) Classification MEMBRANE PROTEIN Compound Soluble cytochrome b562,Delta-type opioid receptor Source (4RWA) Sequence A:  DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQ KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANE GKVKEAQAAAEQLKTTRNAYIQKYLGARSASSLALAIAIT ALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLAL ADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMF TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIW VLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVT KICVFLFAFVVPILIITVCYGLMLLGSKEKDRSLRRITRM VLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHL CIALGYANSSLNPVLYAFLDENFKRCFRQLC B:  DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQ KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANE GKVKEAQAAAEQLKTTRNAYIQKYLGARSASSLALAIAIT ALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLAL ADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMF TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIW VLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVT KICVFLFAFVVPILIITVCYGLMLLRGSKEKDRSLRRITR MVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALH LCIALGYANSSLNPVLYAFLDENFKRCFR Description Functional site 1) chain A residue 137 type sequence F description BINDING SITE FOR RESIDUE OLC A 1201 source : AC1 2) chain A residue 141 type sequence M description BINDING SITE FOR RESIDUE OLC A 1201 source : AC1 3) chain A residue 171 type sequence C description BINDING SITE FOR RESIDUE OLC A 1201 source : AC1 4) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE OLC A 1201 source : AC1 5) chain A residue 225 type sequence P description BINDING SITE FOR RESIDUE OLC A 1201 source : AC1 6) chain B residue 125 type sequence L description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 7) chain B residue 128 type sequence D description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 8) chain B residue 129 type sequence Y description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 9) chain B residue 132 type sequence M description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 10) chain B residue 217 type sequence V description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 11) chain B residue 281 type sequence V description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 12) chain B residue 284 type sequence W description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 13) chain B residue 304 type sequence I description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 14) chain B residue 308 type sequence Y description BINDING SITE FOR CHAIN G OF BIFUNCTIONAL PEPTIDE source : AC2 15) chain A residue 125 type sequence L description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 16) chain A residue 128 type sequence D description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 17) chain A residue 129 type sequence Y description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 18) chain A residue 132 type sequence M description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 19) chain A residue 199 type sequence M description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 20) chain A residue 200 type sequence L description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 21) chain A residue 217 type sequence V description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 22) chain A residue 277 type sequence I description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 23) chain A residue 281 type sequence V description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 24) chain A residue 304 type sequence I description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 25) chain A residue 308 type sequence Y description BINDING SITE FOR CHAIN H OF BIFUNCTIONAL PEPTIDE source : AC3 26) chain A residue 48-75 type TRANSMEM sequence LAIAITALYSAVCAVGLLGNVLVMFGIV description Helical; Name=1 => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 48-75 type TRANSMEM sequence LAIAITALYSAVCAVGLLGNVLVMFGIV description Helical; Name=1 => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 76-85 type TOPO_DOM sequence RYTKMKTATN description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 145-163 type TOPO_DOM sequence DRYIAVCHPVKALDFRTPA description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 76-85 type TOPO_DOM sequence RYTKMKTATN description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 145-163 type TOPO_DOM sequence DRYIAVCHPVKALDFRTPA description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 239-261 type TOPO_DOM sequence RGSKEKDRSLRRITR description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain A residue 86-110 type TRANSMEM sequence IYIFNLALADALATSTLPFQSAKYL description Helical; Name=2 => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 34) chain B residue 86-110 type TRANSMEM sequence IYIFNLALADALATSTLPFQSAKYL description Helical; Name=2 => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 111-122 type TOPO_DOM sequence METWPFGELLCK description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 36) chain A residue 187-206 type TOPO_DOM sequence AVTRPRDGAVVCMLQFPSPS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 37) chain A residue 285-299 type TOPO_DOM sequence TLVDIDRRDPLVVAA description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 38) chain B residue 111-122 type TOPO_DOM sequence METWPFGELLCK description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 39) chain B residue 187-206 type TOPO_DOM sequence AVTRPRDGAVVCMLQFPSPS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 40) chain B residue 285-299 type TOPO_DOM sequence TLVDIDRRDPLVVAA description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 41) chain A residue 123-144 type TRANSMEM sequence AVLSIDYYNMFTSIFTLTMMSV description Helical; Name=3 => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 42) chain B residue 123-144 type TRANSMEM sequence AVLSIDYYNMFTSIFTLTMMSV description Helical; Name=3 => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 43) chain A residue 164-186 type TRANSMEM sequence KAKLINICIWVLASGVGVPIMVM description Helical; Name=4 => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 44) chain B residue 164-186 type TRANSMEM sequence KAKLINICIWVLASGVGVPIMVM description Helical; Name=4 => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 45) chain A residue 207-238 type TRANSMEM sequence WYWDTVTKICVFLFAFVVPILIITVCYGLMLL description Helical; Name=5 => ECO:0000250 source Swiss-Prot : SWS_FT_FI8 46) chain B residue 207-238 type TRANSMEM sequence WYWDTVTKICVFLFAFVVPILIITVCYGLMLL description Helical; Name=5 => ECO:0000250 source Swiss-Prot : SWS_FT_FI8 47) chain A residue 262-284 type TRANSMEM sequence MVLVVVGAFVVCWAPIHIFVIVW description Helical; Name=6 => ECO:0000250 source Swiss-Prot : SWS_FT_FI9 48) chain B residue 262-284 type TRANSMEM sequence MVLVVVGAFVVCWAPIHIFVIVW description Helical; Name=6 => ECO:0000250 source Swiss-Prot : SWS_FT_FI9 49) chain A residue 300-321 type TRANSMEM sequence LHLCIALGYANSSLNPVLYAFL description Helical; Name=7 => ECO:0000250 source Swiss-Prot : SWS_FT_FI10 50) chain B residue 300-321 type TRANSMEM sequence LHLCIALGYANSSLNPVLYAFL description Helical; Name=7 => ECO:0000250 source Swiss-Prot : SWS_FT_FI10 51) chain A residue 333 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000255 source Swiss-Prot : SWS_FT_FI11 52) chain A residue 134-150 type prosite sequence TSIFTLTMMSVDRYIAV description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMSVDRYIaV source prosite : PS00237 53) chain A residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI1 54) chain A residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI1 55) chain B residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI1 56) chain B residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI1

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