eF-site ID 4rv3-A PDB Code 4rv3 Chain A click to enlarge Title Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus Classification LYASE Compound 1-phosphatidylinositol phosphodiesterase Source (PLC_STAAE) Sequence A:  DSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPV KSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHG MVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSK VTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKI VLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLN LKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLS VASGGSAFNSTYNYASXINPEIAKTIKANGKARTGWLIVD YAGYTWPGYDDIVSEIIDSNKL Description (1)  1-phosphatidylinositol phosphodiesterase (E.C.4.6.1.13) Functional site 1) chain A residue 37 type sequence L description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 2) chain A residue 38 type sequence K description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 3) chain A residue 39 type sequence D description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 4) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 5) chain A residue 86 type sequence H description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 6) chain A residue 30 type sequence H description BINDING SITE FOR RESIDUE INS A 402 source : AC2 7) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE INS A 402 source : AC2 8) chain A residue 113 type sequence K description BINDING SITE FOR RESIDUE INS A 402 source : AC2 9) chain A residue 166 type sequence R description BINDING SITE FOR RESIDUE INS A 402 source : AC2 10) chain A residue 206 type sequence D description BINDING SITE FOR RESIDUE INS A 402 source : AC2 11) chain A residue 31 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00270 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 81 type ACT_SITE sequence G description Proton donor => ECO:0000255|PROSITE-ProRule:PRU00270 source Swiss-Prot : SWS_FT_FI2

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