eF-site ID 4rup-A
PDB Code 4rup
Chain A

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Title Crystal structure of zVDR L337H mutant-Gemini72 complex
Classification Transcription Factor
Compound Vitamin D3 receptor A
Source (NCOA1_HUMAN)
Sequence A:  HMLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLS
MLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKS
SAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGH
TLEHLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPG
VQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKL
ADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEV
Description


Functional site

1) chain A
residue 175
type
sequence Y
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

2) chain A
residue 255
type
sequence L
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

3) chain A
residue 262
type
sequence V
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

4) chain A
residue 265
type
sequence S
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

5) chain A
residue 300
type
sequence M
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

6) chain A
residue 302
type
sequence R
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

7) chain A
residue 303
type
sequence S
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

8) chain A
residue 306
type
sequence S
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

9) chain A
residue 314
type
sequence W
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

10) chain A
residue 316
type
sequence C
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

11) chain A
residue 328
type
sequence V
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

12) chain A
residue 331
type
sequence A
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

13) chain A
residue 333
type
sequence H
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

14) chain A
residue 337
type
sequence H
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

15) chain A
residue 338
type
sequence L
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

16) chain A
residue 423
type
sequence H
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

17) chain A
residue 427
type
sequence Y
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

18) chain A
residue 430
type
sequence L
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

19) chain A
residue 440
type
sequence L
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

20) chain A
residue 444
type
sequence V
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

21) chain A
residue 448
type
sequence F
description BINDING SITE FOR RESIDUE H97 A 501
source : AC1

22) chain A
residue 333
type MOD_RES
sequence H
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 423
type MOD_RES
sequence H
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 255
type MOD_RES
sequence L
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

25) chain A
residue 299
type MOD_RES
sequence I
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1


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