eF-site ID 4rt3-ADPT PDB Code 4rt3 Chain A, D, P, T click to enlarge Title Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP Classification TRANSFERASE/DNA Compound DNA polymerase beta Source null (4RT3) Sequence A:  TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKY PHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIR QDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNE DKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKV DSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPK LLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKE YPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEK GFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYRE PKDRSE D:  GTCGG P:  GCTGATGCGX T:  CCGACAGCGCATCAGC Description Functional site 1) chain A residue 190 type sequence D description BINDING SITE FOR RESIDUE MG A 401 source : AC1 2) chain A residue 192 type sequence D description BINDING SITE FOR RESIDUE MG A 401 source : AC1 3) chain A residue 190 type sequence D description BINDING SITE FOR RESIDUE NA A 402 source : AC2 4) chain A residue 192 type sequence D description BINDING SITE FOR RESIDUE NA A 402 source : AC2 5) chain A residue 256 type sequence D description BINDING SITE FOR RESIDUE NA A 402 source : AC2 6) chain A residue 101 type sequence T description BINDING SITE FOR RESIDUE NA A 403 source : AC3 7) chain A residue 103 type sequence V description BINDING SITE FOR RESIDUE NA A 403 source : AC3 8) chain A residue 106 type sequence I description BINDING SITE FOR RESIDUE NA A 403 source : AC3 9) chain P residue 9 type sequence G description BINDING SITE FOR RESIDUE NA A 403 source : AC3 10) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE NA A 404 source : AC4 11) chain A residue 62 type sequence L description BINDING SITE FOR RESIDUE NA A 404 source : AC4 12) chain A residue 65 type sequence V description BINDING SITE FOR RESIDUE NA A 404 source : AC4 13) chain D residue 3 type sequence C description BINDING SITE FOR RESIDUE NA A 404 source : AC4 14) chain A residue 32 type sequence A description BINDING SITE FOR RESIDUE CL A 405 source : AC5 15) chain A residue 34 type sequence H description BINDING SITE FOR RESIDUE CL A 405 source : AC5 16) chain A residue 35 type sequence K description BINDING SITE FOR RESIDUE CL A 405 source : AC5 17) chain A residue 82 type sequence L description BINDING SITE FOR RESIDUE CL A 406 source : AC6 18) chain A residue 89 type sequence R description BINDING SITE FOR RESIDUE CL A 406 source : AC6 19) chain A residue 294 type sequence N description BINDING SITE FOR RESIDUE CL A 407 source : AC7 20) chain A residue 297 type sequence T description BINDING SITE FOR RESIDUE CL A 407 source : AC7 21) chain A residue 179 type sequence G description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 22) chain A residue 180 type sequence S description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 23) chain A residue 183 type sequence R description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 24) chain A residue 188 type sequence S description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 25) chain A residue 189 type sequence G description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 26) chain A residue 190 type sequence D description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 27) chain A residue 192 type sequence D description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 28) chain A residue 271 type sequence Y description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 29) chain A residue 272 type sequence F description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 30) chain A residue 273 type sequence T description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 31) chain A residue 274 type sequence G description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 32) chain A residue 276 type sequence D description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 33) chain A residue 279 type sequence N description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 34) chain P residue 10 type sequence X description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 35) chain T residue 6 type sequence A description BINDING SITE FOR RESIDUE C6T A 408 source : AC8 36) chain A residue 72 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q8K409 source Swiss-Prot : SWS_FT_FI6 37) chain A residue 83 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT6 => ECO:0000269|PubMed:16600869 source Swiss-Prot : SWS_FT_FI7 38) chain A residue 152 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT6 => ECO:0000269|PubMed:16600869 source Swiss-Prot : SWS_FT_FI7 39) chain A residue 41 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:21362556 source Swiss-Prot : SWS_FT_FI8 40) chain A residue 61 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:21362556 source Swiss-Prot : SWS_FT_FI8 41) chain A residue 81 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:21362556 source Swiss-Prot : SWS_FT_FI8 42) chain A residue 183 type BINDING sequence R description BINDING => ECO:0000269|PubMed:8841119, ECO:0007744|PDB:8ICX source Swiss-Prot : SWS_FT_FI4 43) chain A residue 256 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPY source Swiss-Prot : SWS_FT_FI5 44) chain A residue 192 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPY source Swiss-Prot : SWS_FT_FI5 45) chain A residue 190 type BINDING sequence D description BINDING => ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPY source Swiss-Prot : SWS_FT_FI5 46) chain A residue 179-198 type prosite sequence GSFRRGAESSGDMDVLLTHP description DNA_POLYMERASE_X DNA polymerase family X signature. GSFrRGaesSgDMDVLLthP source prosite : PS00522 47) chain A residue 72 type ACT_SITE sequence K description Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity => ECO:0000269|PubMed:9572863 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 101 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12517346, ECO:0000269|PubMed:8841120, ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPX, ECO:0007744|PDB:1BPZ, ECO:0007744|PDB:1MQ3, ECO:0007744|PDB:1ZQO, ECO:0007744|PDB:1ZQQ source Swiss-Prot : SWS_FT_FI2 49) chain A residue 103 type BINDING sequence V description BINDING => ECO:0000269|PubMed:12517346, ECO:0000269|PubMed:8841120, ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPX, ECO:0007744|PDB:1BPZ, ECO:0007744|PDB:1MQ3, ECO:0007744|PDB:1ZQO, ECO:0007744|PDB:1ZQQ source Swiss-Prot : SWS_FT_FI2 50) chain A residue 106 type BINDING sequence I description BINDING => ECO:0000269|PubMed:12517346, ECO:0000269|PubMed:8841120, ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPX, ECO:0007744|PDB:1BPZ, ECO:0007744|PDB:1MQ3, ECO:0007744|PDB:1ZQO, ECO:0007744|PDB:1ZQQ source Swiss-Prot : SWS_FT_FI2 51) chain A residue 65 type BINDING sequence V description BINDING => ECO:0000269|PubMed:12517346, ECO:0000269|PubMed:8841120, ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPX, ECO:0007744|PDB:1BPZ, ECO:0007744|PDB:1MQ3, ECO:0007744|PDB:1ZQO, ECO:0007744|PDB:1ZQQ source Swiss-Prot : SWS_FT_FI2 52) chain A residue 60 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12517346, ECO:0000269|PubMed:8841120, ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPX, ECO:0007744|PDB:1BPZ, ECO:0007744|PDB:1MQ3, ECO:0007744|PDB:1ZQO, ECO:0007744|PDB:1ZQQ source Swiss-Prot : SWS_FT_FI2 53) chain A residue 62 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12517346, ECO:0000269|PubMed:8841120, ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPX, ECO:0007744|PDB:1BPZ, ECO:0007744|PDB:1MQ3, ECO:0007744|PDB:1ZQO, ECO:0007744|PDB:1ZQQ source Swiss-Prot : SWS_FT_FI2 54) chain A residue 180 type BINDING sequence S description BINDING => ECO:0000269|PubMed:8841119, ECO:0007744|PDB:8ICW, ECO:0007744|PDB:8ICX, ECO:0007744|PDB:8ICY source Swiss-Prot : SWS_FT_FI3 55) chain A residue 189 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8841119, ECO:0007744|PDB:8ICW, ECO:0007744|PDB:8ICX, ECO:0007744|PDB:8ICY source Swiss-Prot : SWS_FT_FI3 56) chain A residue 149 type BINDING sequence R description BINDING => ECO:0000269|PubMed:8841119, ECO:0007744|PDB:8ICW, ECO:0007744|PDB:8ICX, ECO:0007744|PDB:8ICY source Swiss-Prot : SWS_FT_FI3

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