eF-site ID 4rr4-A PDB Code 4rr4 Chain A click to enlarge Title Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367 Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Compound Dihydroorotate dehydrogenase (quinone), mitochondrial Source Homo sapiens (Human) (PYRD_HUMAN) Sequence A:  TGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRA RFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKM GFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNS HGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDA AEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELR RLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASV VKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRD LSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGAS LVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIG ADHRR Description Functional site 1) chain A residue 95 type sequence A description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 2) chain A residue 96 type sequence A description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 3) chain A residue 97 type sequence G description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 4) chain A residue 100 type sequence K description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 5) chain A residue 120 type sequence S description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 6) chain A residue 145 type sequence N description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 7) chain A residue 147 type sequence Y description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 8) chain A residue 181 type sequence N description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 9) chain A residue 212 type sequence N description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 10) chain A residue 255 type sequence K description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 11) chain A residue 283 type sequence T description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 12) chain A residue 284 type sequence N description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 13) chain A residue 285 type sequence T description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 14) chain A residue 305 type sequence S description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 15) chain A residue 306 type sequence G description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 16) chain A residue 309 type sequence L description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 17) chain A residue 333 type sequence V description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 18) chain A residue 334 type sequence G description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 19) chain A residue 335 type sequence G description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 20) chain A residue 355 type sequence L description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 21) chain A residue 356 type sequence Y description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 22) chain A residue 357 type sequence T description BINDING SITE FOR RESIDUE FMN A 401 source : AC1 23) chain A residue 100 type sequence K description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 24) chain A residue 145 type sequence N description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 25) chain A residue 147 type sequence Y description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 26) chain A residue 148 type sequence G description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 27) chain A residue 149 type sequence F description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 28) chain A residue 212 type sequence N description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 29) chain A residue 215 type sequence S description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 30) chain A residue 217 type sequence N description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 31) chain A residue 284 type sequence N description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 32) chain A residue 285 type sequence T description BINDING SITE FOR RESIDUE ORO A 402 source : AC2 33) chain A residue 38 type sequence Y description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 34) chain A residue 43 type sequence M description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 35) chain A residue 52 type sequence P description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 36) chain A residue 56 type sequence H description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 37) chain A residue 59 type sequence A description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 38) chain A residue 62 type sequence F description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 39) chain A residue 63 type sequence T description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 40) chain A residue 67 type sequence L description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 41) chain A residue 68 type sequence L description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 42) chain A residue 136 type sequence R description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 43) chain A residue 360 type sequence T description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 44) chain A residue 364 type sequence P description BINDING SITE FOR RESIDUE 3V1 A 403 source : AC3 45) chain A residue 245 type sequence R description BINDING SITE FOR RESIDUE SO4 A 404 source : AC4 46) chain A residue 247 type sequence V description BINDING SITE FOR RESIDUE SO4 A 404 source : AC4 47) chain A residue 248 type sequence H description BINDING SITE FOR RESIDUE SO4 A 404 source : AC4 48) chain A residue 246 type sequence R description BINDING SITE FOR RESIDUE SO4 A 405 source : AC5 49) chain A residue 249 type sequence R description BINDING SITE FOR RESIDUE SO4 A 405 source : AC5 50) chain A residue 145 type catalytic sequence N description 109 source MCSA : MCSA1 51) chain A residue 149 type catalytic sequence F description 109 source MCSA : MCSA1 52) chain A residue 215 type catalytic sequence S description 109 source MCSA : MCSA1 53) chain A residue 217 type catalytic sequence N description 109 source MCSA : MCSA1 54) chain A residue 218 type catalytic sequence T description 109 source MCSA : MCSA1 55) chain A residue 255 type catalytic sequence K description 109 source MCSA : MCSA1 56) chain A residue 284 type catalytic sequence N description 109 source MCSA : MCSA1 57) chain A residue 114-133 type prosite sequence GFVEIGSVTPKPQEGNPRPR description DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GfveiGSVTpkpQeGNprPR source prosite : PS00911 58) chain A residue 330-350 type prosite sequence IIGVGGVSSGQDALEKIRAGA description DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGvGGVsSgqdAleKIrAGA source prosite : PS00912 59) chain A residue 215 type ACT_SITE sequence S description Nucleophile source Swiss-Prot : SWS_FT_FI2 60) chain A residue 32-396 type TOPO_DOM sequence TGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRA RFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKM GFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNS HGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDA AEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELR RLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASV VKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRD LSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGAS LVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIG ADHRR description Mitochondrial intermembrane => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 96 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 62) chain A residue 120 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 63) chain A residue 181 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 64) chain A residue 212 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 65) chain A residue 255 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 66) chain A residue 283 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 67) chain A residue 306 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 68) chain A residue 335 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 69) chain A residue 356 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10673429, ECO:0000269|PubMed:16480261 source Swiss-Prot : SWS_FT_FI3 70) chain A residue 100 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI4 71) chain A residue 145 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI4 72) chain A residue 284 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI4

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