|
eF-site ID
|
4rnq-A |
PDB Code
|
4rnq |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline |
Classification
|
LYASE |
Compound
|
5-epi-aristolochene synthase |
Source
|
Nicotiana tabacum (Common tobacco) (5EAS_TOBAC) |
|
Sequence
|
A: |
IVRPVADFSPSLWGDQFLSFSIKNQVAEKYAKEIEALKEQ
TRNMLLATGMKLADTLNLIDTIERLGISYHFEKEIDDILD
QIYNQNSNCNDLCTSALQFRLLRQHGFNISPEIFSKFQDE
NGKFKESLASDVLGLLNLYEASHVRTHADDILEDALAFST
IHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFIS
SIYDKEQSKNNVLLRFAKLDFNLLQMLHKQELAQVSRWWK
DLDFVTTLPYARDRVVECYFWALGVYFEPQYSQARVMLVK
TISMISIVDDTFDAYGTVKELEAYTDAIQRWDINEIDRLP
DYMKISYKAILDLYKDYEKELSSAGRSHIVCHAIERMKEV
VRNYNVESTWFIEGYTPPVSEYLSNALATTTYYYLATTSY
LGMKSATEQDFEWLSKNPKILEASVIICRVIDDTATYEVE
KSRGQIATGIECCMRDYGISTKEAMAKFQNMAETAWKDIN
EGLLRPTPVSTEFLTPILNLARIVEVTYIHNLDGYTHPEK
VLKPHIINLLVDSIKI
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
301 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG A 601
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
305 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG A 601
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
379 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE MG A 601
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
301 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG A 602
|
source |
: AC2
|
|
5)
|
chain |
A |
residue |
305 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG A 602
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
444 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG A 603
|
source |
: AC3
|
|
7)
|
chain |
A |
residue |
445 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG A 603
|
source |
: AC3
|
|
8)
|
chain |
A |
residue |
448 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE MG A 603
|
source |
: AC3
|
|
9)
|
chain |
A |
residue |
452 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE MG A 603
|
source |
: AC3
|
|
10)
|
chain |
A |
residue |
264 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
11)
|
chain |
A |
residue |
273 |
type |
|
sequence |
W
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
12)
|
chain |
A |
residue |
294 |
type |
|
sequence |
I
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
13)
|
chain |
A |
residue |
297 |
type |
|
sequence |
I
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
14)
|
chain |
A |
residue |
298 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
15)
|
chain |
A |
residue |
305 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
16)
|
chain |
A |
residue |
402 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
17)
|
chain |
A |
residue |
403 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
18)
|
chain |
A |
residue |
407 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
19)
|
chain |
A |
residue |
440 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
20)
|
chain |
A |
residue |
441 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
21)
|
chain |
A |
residue |
444 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
22)
|
chain |
A |
residue |
452 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
23)
|
chain |
A |
residue |
520 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
24)
|
chain |
A |
residue |
527 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE A4S A 604
|
source |
: AC4
|
|
25)
|
chain |
A |
residue |
264 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE 1GA A 605
|
source |
: AC5
|
|
26)
|
chain |
A |
residue |
273 |
type |
|
sequence |
W
|
description |
BINDING SITE FOR RESIDUE 1GA A 605
|
source |
: AC5
|
|
27)
|
chain |
A |
residue |
402 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE 1GA A 605
|
source |
: AC5
|
|
28)
|
chain |
A |
residue |
403 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE 1GA A 605
|
source |
: AC5
|
|
29)
|
chain |
A |
residue |
407 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE 1GA A 605
|
source |
: AC5
|
|
30)
|
chain |
A |
residue |
520 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE 1GA A 605
|
source |
: AC5
|
|
31)
|
chain |
A |
residue |
527 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE 1GA A 605
|
source |
: AC5
|
|
32)
|
chain |
A |
residue |
264 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE DPO A 606
|
source |
: AC6
|
|
33)
|
chain |
A |
residue |
301 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE DPO A 606
|
source |
: AC6
|
|
34)
|
chain |
A |
residue |
305 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE DPO A 606
|
source |
: AC6
|
|
35)
|
chain |
A |
residue |
441 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE DPO A 606
|
source |
: AC6
|
|
36)
|
chain |
A |
residue |
444 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE DPO A 606
|
source |
: AC6
|
|
37)
|
chain |
A |
residue |
452 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE DPO A 606
|
source |
: AC6
|
|
38)
|
chain |
A |
residue |
154 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE ACT A 607
|
source |
: AC7
|
|
39)
|
chain |
A |
residue |
155 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ACT A 607
|
source |
: AC7
|
|
40)
|
chain |
A |
residue |
157 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE ACT A 607
|
source |
: AC7
|
|
41)
|
chain |
A |
residue |
200 |
type |
|
sequence |
K
|
description |
BINDING SITE FOR RESIDUE ACT A 607
|
source |
: AC7
|
|
42)
|
chain |
A |
residue |
485 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE ACT A 607
|
source |
: AC7
|
|
43)
|
chain |
A |
residue |
488 |
type |
|
sequence |
W
|
description |
BINDING SITE FOR RESIDUE ACT A 607
|
source |
: AC7
|
|
44)
|
chain |
A |
residue |
492 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE ACT A 607
|
source |
: AC7
|
|
45)
|
chain |
A |
residue |
264 |
type |
catalytic |
sequence |
R
|
description |
265
|
source |
MCSA : MCSA1
|
|
46)
|
chain |
A |
residue |
527 |
type |
catalytic |
sequence |
Y
|
description |
265
|
source |
MCSA : MCSA1
|
|
47)
|
chain |
A |
residue |
273 |
type |
catalytic |
sequence |
W
|
description |
265
|
source |
MCSA : MCSA1
|
|
48)
|
chain |
A |
residue |
401 |
type |
catalytic |
sequence |
T
|
description |
265
|
source |
MCSA : MCSA1
|
|
49)
|
chain |
A |
residue |
402 |
type |
catalytic |
sequence |
T
|
description |
265
|
source |
MCSA : MCSA1
|
|
50)
|
chain |
A |
residue |
403 |
type |
catalytic |
sequence |
T
|
description |
265
|
source |
MCSA : MCSA1
|
|
51)
|
chain |
A |
residue |
441 |
type |
catalytic |
sequence |
R
|
description |
265
|
source |
MCSA : MCSA1
|
|
52)
|
chain |
A |
residue |
444 |
type |
catalytic |
sequence |
D
|
description |
265
|
source |
MCSA : MCSA1
|
|
53)
|
chain |
A |
residue |
520 |
type |
catalytic |
sequence |
Y
|
description |
265
|
source |
MCSA : MCSA1
|
|
54)
|
chain |
A |
residue |
525 |
type |
catalytic |
sequence |
D
|
description |
265
|
source |
MCSA : MCSA1
|
|
55)
|
chain |
A |
residue |
264 |
type |
BINDING |
sequence |
R
|
description |
BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:27328867, ECO:0000305|PubMed:25897591, ECO:0000305|PubMed:9295271, ECO:0000305|Ref.13, ECO:0000305|Ref.9, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5IL8, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILY
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
56)
|
chain |
A |
residue |
301 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
57)
|
chain |
A |
residue |
305 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5DHK, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
58)
|
chain |
A |
residue |
441 |
type |
BINDING |
sequence |
R
|
description |
BINDING => ECO:0000269|PubMed:27328867, ECO:0000305|PubMed:20175559, ECO:0000305|PubMed:25897591, ECO:0000305|PubMed:27328867, ECO:0000305|Ref.13, ECO:0000305|Ref.7, ECO:0000305|Ref.9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:1HXC, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IL3, ECO:0007744|PDB:5ILH, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
59)
|
chain |
A |
residue |
444 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PDB:1HX9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5IL3, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
60)
|
chain |
A |
residue |
452 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PDB:1HX9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5IL3, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
61)
|
chain |
A |
residue |
445 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.9, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5ILD
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
62)
|
chain |
A |
residue |
448 |
type |
BINDING |
sequence |
T
|
description |
BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PDB:1HX9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
|
|