eF-site ID 4rnq-A
PDB Code 4rnq
Chain A

click to enlarge
Title Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline
Classification LYASE
Compound 5-epi-aristolochene synthase
Source Nicotiana tabacum (Common tobacco) (5EAS_TOBAC)
Sequence A:  IVRPVADFSPSLWGDQFLSFSIKNQVAEKYAKEIEALKEQ
TRNMLLATGMKLADTLNLIDTIERLGISYHFEKEIDDILD
QIYNQNSNCNDLCTSALQFRLLRQHGFNISPEIFSKFQDE
NGKFKESLASDVLGLLNLYEASHVRTHADDILEDALAFST
IHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFIS
SIYDKEQSKNNVLLRFAKLDFNLLQMLHKQELAQVSRWWK
DLDFVTTLPYARDRVVECYFWALGVYFEPQYSQARVMLVK
TISMISIVDDTFDAYGTVKELEAYTDAIQRWDINEIDRLP
DYMKISYKAILDLYKDYEKELSSAGRSHIVCHAIERMKEV
VRNYNVESTWFIEGYTPPVSEYLSNALATTTYYYLATTSY
LGMKSATEQDFEWLSKNPKILEASVIICRVIDDTATYEVE
KSRGQIATGIECCMRDYGISTKEAMAKFQNMAETAWKDIN
EGLLRPTPVSTEFLTPILNLARIVEVTYIHNLDGYTHPEK
VLKPHIINLLVDSIKI
Description


Functional site
1) chain A
residue 301
type
sequence D
description BINDING SITE FOR RESIDUE MG A 601
source : AC1
2) chain A
residue 305
type
sequence D
description BINDING SITE FOR RESIDUE MG A 601
source : AC1
3) chain A
residue 379
type
sequence E
description BINDING SITE FOR RESIDUE MG A 601
source : AC1
4) chain A
residue 301
type
sequence D
description BINDING SITE FOR RESIDUE MG A 602
source : AC2
5) chain A
residue 305
type
sequence D
description BINDING SITE FOR RESIDUE MG A 602
source : AC2
6) chain A
residue 444
type
sequence D
description BINDING SITE FOR RESIDUE MG A 603
source : AC3
7) chain A
residue 445
type
sequence D
description BINDING SITE FOR RESIDUE MG A 603
source : AC3
8) chain A
residue 448
type
sequence T
description BINDING SITE FOR RESIDUE MG A 603
source : AC3
9) chain A
residue 452
type
sequence E
description BINDING SITE FOR RESIDUE MG A 603
source : AC3
10) chain A
residue 264
type
sequence R
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
11) chain A
residue 273
type
sequence W
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
12) chain A
residue 294
type
sequence I
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
13) chain A
residue 297
type
sequence I
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
14) chain A
residue 298
type
sequence S
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
15) chain A
residue 305
type
sequence D
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
16) chain A
residue 402
type
sequence T
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
17) chain A
residue 403
type
sequence T
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
18) chain A
residue 407
type
sequence L
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
19) chain A
residue 440
type
sequence C
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
20) chain A
residue 441
type
sequence R
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
21) chain A
residue 444
type
sequence D
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
22) chain A
residue 452
type
sequence E
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
23) chain A
residue 520
type
sequence Y
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
24) chain A
residue 527
type
sequence Y
description BINDING SITE FOR RESIDUE A4S A 604
source : AC4
25) chain A
residue 264
type
sequence R
description BINDING SITE FOR RESIDUE 1GA A 605
source : AC5
26) chain A
residue 273
type
sequence W
description BINDING SITE FOR RESIDUE 1GA A 605
source : AC5
27) chain A
residue 402
type
sequence T
description BINDING SITE FOR RESIDUE 1GA A 605
source : AC5
28) chain A
residue 403
type
sequence T
description BINDING SITE FOR RESIDUE 1GA A 605
source : AC5
29) chain A
residue 407
type
sequence L
description BINDING SITE FOR RESIDUE 1GA A 605
source : AC5
30) chain A
residue 520
type
sequence Y
description BINDING SITE FOR RESIDUE 1GA A 605
source : AC5
31) chain A
residue 527
type
sequence Y
description BINDING SITE FOR RESIDUE 1GA A 605
source : AC5
32) chain A
residue 264
type
sequence R
description BINDING SITE FOR RESIDUE DPO A 606
source : AC6
33) chain A
residue 301
type
sequence D
description BINDING SITE FOR RESIDUE DPO A 606
source : AC6
34) chain A
residue 305
type
sequence D
description BINDING SITE FOR RESIDUE DPO A 606
source : AC6
35) chain A
residue 441
type
sequence R
description BINDING SITE FOR RESIDUE DPO A 606
source : AC6
36) chain A
residue 444
type
sequence D
description BINDING SITE FOR RESIDUE DPO A 606
source : AC6
37) chain A
residue 452
type
sequence E
description BINDING SITE FOR RESIDUE DPO A 606
source : AC6
38) chain A
residue 154
type
sequence S
description BINDING SITE FOR RESIDUE ACT A 607
source : AC7
39) chain A
residue 155
type
sequence H
description BINDING SITE FOR RESIDUE ACT A 607
source : AC7
40) chain A
residue 157
type
sequence R
description BINDING SITE FOR RESIDUE ACT A 607
source : AC7
41) chain A
residue 200
type
sequence K
description BINDING SITE FOR RESIDUE ACT A 607
source : AC7
42) chain A
residue 485
type
sequence E
description BINDING SITE FOR RESIDUE ACT A 607
source : AC7
43) chain A
residue 488
type
sequence W
description BINDING SITE FOR RESIDUE ACT A 607
source : AC7
44) chain A
residue 492
type
sequence N
description BINDING SITE FOR RESIDUE ACT A 607
source : AC7
45) chain A
residue 264
type catalytic
sequence R
description 265
source MCSA : MCSA1
46) chain A
residue 527
type catalytic
sequence Y
description 265
source MCSA : MCSA1
47) chain A
residue 273
type catalytic
sequence W
description 265
source MCSA : MCSA1
48) chain A
residue 401
type catalytic
sequence T
description 265
source MCSA : MCSA1
49) chain A
residue 402
type catalytic
sequence T
description 265
source MCSA : MCSA1
50) chain A
residue 403
type catalytic
sequence T
description 265
source MCSA : MCSA1
51) chain A
residue 441
type catalytic
sequence R
description 265
source MCSA : MCSA1
52) chain A
residue 444
type catalytic
sequence D
description 265
source MCSA : MCSA1
53) chain A
residue 520
type catalytic
sequence Y
description 265
source MCSA : MCSA1
54) chain A
residue 525
type catalytic
sequence D
description 265
source MCSA : MCSA1
55) chain A
residue 264
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:27328867, ECO:0000305|PubMed:25897591, ECO:0000305|PubMed:9295271, ECO:0000305|Ref.13, ECO:0000305|Ref.9, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5IL8, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILY
source Swiss-Prot : SWS_FT_FI1
56) chain A
residue 301
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA
source Swiss-Prot : SWS_FT_FI2
57) chain A
residue 305
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5DHK, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA
source Swiss-Prot : SWS_FT_FI3
58) chain A
residue 441
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:27328867, ECO:0000305|PubMed:20175559, ECO:0000305|PubMed:25897591, ECO:0000305|PubMed:27328867, ECO:0000305|Ref.13, ECO:0000305|Ref.7, ECO:0000305|Ref.9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:1HXC, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IL3, ECO:0007744|PDB:5ILH, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
source Swiss-Prot : SWS_FT_FI4
59) chain A
residue 444
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PDB:1HX9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5IL3, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
source Swiss-Prot : SWS_FT_FI5
60) chain A
residue 452
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PDB:1HX9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK0, ECO:0007744|PDB:5IK6, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5IL3, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
source Swiss-Prot : SWS_FT_FI5
61) chain A
residue 445
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.9, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5ILD
source Swiss-Prot : SWS_FT_FI6
62) chain A
residue 448
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:20175559, ECO:0000269|PubMed:25897591, ECO:0000269|PubMed:26378620, ECO:0000269|PubMed:27328867, ECO:0000269|PubMed:9295271, ECO:0000269|Ref.13, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PDB:1HX9, ECO:0007744|PDB:1HXA, ECO:0007744|PDB:3LZ9, ECO:0007744|PDB:3M00, ECO:0007744|PDB:3M01, ECO:0007744|PDB:3M02, ECO:0007744|PDB:4DI5, ECO:0007744|PDB:4RNQ, ECO:0007744|PDB:5DHI, ECO:0007744|PDB:5EAS, ECO:0007744|PDB:5EAT, ECO:0007744|PDB:5EAU, ECO:0007744|PDB:5IK9, ECO:0007744|PDB:5IKA, ECO:0007744|PDB:5IKH, ECO:0007744|PDB:5ILD, ECO:0007744|PDB:5ILI, ECO:0007744|PDB:5ILY
source Swiss-Prot : SWS_FT_FI7

Display surface

Download
Links