eF-site ID 4rma-AB PDB Code 4rma Chain A, B click to enlarge Title Crystal structure of the FERM domain of human ezrin Classification PEPTIDE BINDING PROTEIN Compound Ezrin Source Homo sapiens (Human) (EZRI_HUMAN) Sequence A:  PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLRE VWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFR AKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQH KLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMY GINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRIL QLCMGNHELYMRRRK B:  PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLRE VWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFR AKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET AVLLGSYAVQAKFGDYGYERLIPQRVMDQHKLTRDQWEDR IQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNK KGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN DKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELY MRRRK Description Functional site 1) chain A residue 95 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 2) chain A residue 96 type sequence D description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 3) chain A residue 97 type sequence I description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 4) chain A residue 273 type sequence R description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 5) chain A residue 274 type sequence L description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 6) chain B residue 209 type sequence K description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 7) chain B residue 95 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 301 source : AC3 8) chain B residue 96 type sequence D description BINDING SITE FOR RESIDUE SO4 B 301 source : AC3 9) chain B residue 97 type sequence I description BINDING SITE FOR RESIDUE SO4 B 301 source : AC3 10) chain A residue 209 type sequence K description BINDING SITE FOR RESIDUE SO4 B 302 source : AC4 11) chain B residue 273 type sequence R description BINDING SITE FOR RESIDUE SO4 B 302 source : AC4 12) chain B residue 274 type sequence L description BINDING SITE FOR RESIDUE SO4 B 302 source : AC4 13) chain A residue 60 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 60 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 146 type MOD_RES sequence Y description Phosphotyrosine; by PDGFR => ECO:0000269|PubMed:1382070, ECO:0000269|PubMed:18046454 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 146 type MOD_RES sequence Y description Phosphotyrosine; by PDGFR => ECO:0000269|PubMed:1382070, ECO:0000269|PubMed:18046454 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 58-88 type prosite sequence WLKLDKKVSAQEVRKENPLQFKFRAKFYPED description FERM_1 FERM domain signature 1. WLkldKkVsaQe.Vrkenplq.FkfrakFYpeD source prosite : PS00660 18) chain A residue 176-205 type prosite sequence HAEHRGMLKDNAMLEYLKIAQDLEMYGINY description FERM_2 FERM domain signature 2. HaehrgmlkdNAmleYLki.AqdLemYGiNY source prosite : PS00661

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