eF-site ID 4rm8-AB PDB Code 4rm8 Chain A, B click to enlarge Title Crystal structure of human ezrin in space group P21 Classification PEPTIDE BINDING PROTEIN Compound Ezrin Source Homo sapiens (Human) (EZRI_HUMAN) Sequence A:  MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLR EVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKF RAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQ HKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEM YGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRI LQLCMGNHELYMRRRKPKRITEAEKNERVQRQLLTLSSEL SQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQ RIDEFEAL B:  KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREV WYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRA KFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETA VLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHK LTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYG INYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPW SEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQ LCMGNHELYMRRRKPEKRITEAEKNERVQRQLLTLSSELS QARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQR IDEFEAL Description Functional site 1) chain A residue 58-88 type prosite sequence WLKLDKKVSAQEVRKENPLQFKFRAKFYPED description FERM_1 FERM domain signature 1. WLkldKkVsaQe.Vrkenplq.FkfrakFYpeD source prosite : PS00660 2) chain A residue 176-205 type prosite sequence HAEHRGMLKDNAMLEYLKIAQDLEMYGINY description FERM_2 FERM domain signature 2. HaehrgmlkdNAmleYLki.AqdLemYGiNY source prosite : PS00661 3) chain A residue 535 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P26040 source Swiss-Prot : SWS_FT_FI6 4) chain B residue 535 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P26040 source Swiss-Prot : SWS_FT_FI6 5) chain A residue 567 type MOD_RES sequence T description Phosphothreonine; by ROCK2 and PKC/PRKCI => ECO:0000305|PubMed:18270268 source Swiss-Prot : SWS_FT_FI7 6) chain B residue 567 type MOD_RES sequence T description Phosphothreonine; by ROCK2 and PKC/PRKCI => ECO:0000305|PubMed:18270268 source Swiss-Prot : SWS_FT_FI7 7) chain A residue 60 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 60 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 146 type MOD_RES sequence Y description Phosphotyrosine; by PDGFR => ECO:0000269|PubMed:1382070, ECO:0000269|PubMed:18046454 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 146 type MOD_RES sequence Y description Phosphotyrosine; by PDGFR => ECO:0000269|PubMed:1382070, ECO:0000269|PubMed:18046454 source Swiss-Prot : SWS_FT_FI2

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