|
|
eF-site ID
|
4rlt-B |
|
PDB Code
|
4rlt |
|
Chain
|
B |
|
click to enlarge
|
|
|
Title
|
Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium tuberculosis complexed with Fisetin |
|
Classification
|
LYASE/LYASE INHIBITOR |
|
Compound
|
(3R)-hydroxyacyl-ACP dehydratase subunit HadA |
|
Source
|
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (I6WYY7_MYCTU) |
|
|
Sequence
|
B: |
GPLGSMALREFSSVKVGDQLPEKTYPLTRQDLVNYAGVSG
DLNPIHWDDEIAKVVGLDTAIAHGMLTMGIGGGYVTSWVG
DPGAVTEYNVRFTAVVPVPNDGKGAELVFNGRVKSVDPES
KSVTIALTATTGGKKIFGRAIASAKLA
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
60 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE FSE A 201
|
| source |
: AC1
|
|
|
2)
|
chain |
B |
| residue |
11 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE GOL B 201
|
| source |
: AC3
|
|
|
3)
|
chain |
B |
| residue |
107 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE GOL B 201
|
| source |
: AC3
|
|
|
4)
|
chain |
B |
| residue |
109 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE GOL B 201
|
| source |
: AC3
|
|
|
5)
|
chain |
B |
| residue |
56-66 |
| type |
prosite |
| sequence |
IAHGMLTMGIG
|
| description |
THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. IAHGMLTMGIG
|
| source |
prosite : PS00639
|
|
|
|