|
|
eF-site ID
|
4rla-ABC |
|
PDB Code
|
4rla |
|
Chain
|
A, B, C |
|
click to enlarge
|
|
|
Title
|
ALTERING THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE DIMINISHES THERMOSTABILITY AND CATALYTIC FUNCTION |
|
Classification
|
HYDROLASE |
|
Compound
|
ARGINASE |
|
Source
|
Rattus norvegicus (Rat) (ARGI1_RAT) |
|
|
Sequence
|
A: |
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEY
NVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVA
ETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDA
HTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWV
TPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDK
LGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATG
TPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKT
PEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
|
| B: |
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEY
NVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVA
ETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDA
HTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWV
TPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDK
LGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATG
TPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKT
PEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
|
| C: |
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEY
NVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVA
ETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDA
HTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWV
TPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDK
LGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATG
TPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKT
PEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
101 |
| type |
|
| sequence |
N
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNA
|
|
|
2)
|
chain |
A |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNA
|
|
|
3)
|
chain |
A |
| residue |
126 |
| type |
|
| sequence |
H
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNA
|
|
|
4)
|
chain |
A |
| residue |
128 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNA
|
|
|
5)
|
chain |
A |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNA
|
|
|
6)
|
chain |
A |
| residue |
234 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNA
|
|
|
7)
|
chain |
B |
| residue |
101 |
| type |
|
| sequence |
N
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNB
|
|
|
8)
|
chain |
B |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNB
|
|
|
9)
|
chain |
B |
| residue |
126 |
| type |
|
| sequence |
H
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNB
|
|
|
10)
|
chain |
B |
| residue |
128 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNB
|
|
|
11)
|
chain |
B |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNB
|
|
|
12)
|
chain |
B |
| residue |
234 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNB
|
|
|
13)
|
chain |
C |
| residue |
101 |
| type |
|
| sequence |
N
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNC
|
|
|
14)
|
chain |
C |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNC
|
|
|
15)
|
chain |
C |
| residue |
126 |
| type |
|
| sequence |
H
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNC
|
|
|
16)
|
chain |
C |
| residue |
128 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNC
|
|
|
17)
|
chain |
C |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNC
|
|
|
18)
|
chain |
C |
| residue |
234 |
| type |
|
| sequence |
D
|
| description |
BI-MANGANESE NUCLEAR BINDING SITE.
|
| source |
: MNC
|
|
|
19)
|
chain |
A |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN A 500
|
| source |
: AC1
|
|
|
20)
|
chain |
A |
| residue |
126 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN A 500
|
| source |
: AC1
|
|
|
21)
|
chain |
A |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN A 500
|
| source |
: AC1
|
|
|
22)
|
chain |
A |
| residue |
234 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN A 500
|
| source |
: AC1
|
|
|
23)
|
chain |
B |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 501
|
| source |
: AC2
|
|
|
24)
|
chain |
B |
| residue |
126 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN B 501
|
| source |
: AC2
|
|
|
25)
|
chain |
B |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 501
|
| source |
: AC2
|
|
|
26)
|
chain |
B |
| residue |
234 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 501
|
| source |
: AC2
|
|
|
27)
|
chain |
C |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN C 502
|
| source |
: AC3
|
|
|
28)
|
chain |
C |
| residue |
126 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN C 502
|
| source |
: AC3
|
|
|
29)
|
chain |
C |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN C 502
|
| source |
: AC3
|
|
|
30)
|
chain |
C |
| residue |
234 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN C 502
|
| source |
: AC3
|
|
|
31)
|
chain |
A |
| residue |
230-251 |
| type |
prosite |
| sequence |
SFDVDGLDPVFTPATGTPVVGG
|
| description |
ARGINASE_1 Arginase family signature. SFDVDgldPvftPAtgtpvvgG
|
| source |
prosite : PS01053
|
|
|
32)
|
chain |
A |
| residue |
17 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
33)
|
chain |
A |
| residue |
75 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
34)
|
chain |
B |
| residue |
17 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
35)
|
chain |
B |
| residue |
75 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
36)
|
chain |
C |
| residue |
17 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
37)
|
chain |
C |
| residue |
75 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
38)
|
chain |
A |
| residue |
62 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:22673903
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
39)
|
chain |
B |
| residue |
62 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:22673903
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
40)
|
chain |
C |
| residue |
62 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:22673903
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
41)
|
chain |
A |
| residue |
72 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI12
|
|
|
42)
|
chain |
B |
| residue |
72 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI12
|
|
|
43)
|
chain |
C |
| residue |
72 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI12
|
|
|
44)
|
chain |
A |
| residue |
163 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
45)
|
chain |
A |
| residue |
217 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
46)
|
chain |
B |
| residue |
163 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
47)
|
chain |
B |
| residue |
217 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
48)
|
chain |
C |
| residue |
163 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
49)
|
chain |
C |
| residue |
217 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
50)
|
chain |
A |
| residue |
246 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000250|UniProtKB:P53608
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
51)
|
chain |
B |
| residue |
246 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000250|UniProtKB:P53608
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
52)
|
chain |
C |
| residue |
246 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000250|UniProtKB:P53608
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
53)
|
chain |
A |
| residue |
277 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:P78540
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
54)
|
chain |
B |
| residue |
277 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:P78540
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
55)
|
chain |
C |
| residue |
277 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:P78540
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
56)
|
chain |
A |
| residue |
101 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
57)
|
chain |
B |
| residue |
101 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
58)
|
chain |
C |
| residue |
101 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
59)
|
chain |
A |
| residue |
124 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
60)
|
chain |
A |
| residue |
126 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
61)
|
chain |
B |
| residue |
124 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
62)
|
chain |
B |
| residue |
126 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
63)
|
chain |
C |
| residue |
124 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
64)
|
chain |
C |
| residue |
126 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
65)
|
chain |
A |
| residue |
137 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
66)
|
chain |
B |
| residue |
137 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
67)
|
chain |
C |
| residue |
137 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
68)
|
chain |
A |
| residue |
183 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0007744|PDB:1T5G
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
69)
|
chain |
B |
| residue |
183 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0007744|PDB:1T5G
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
70)
|
chain |
C |
| residue |
183 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0007744|PDB:1T5G
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
71)
|
chain |
A |
| residue |
281 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:22673903
|
| source |
Swiss-Prot : SWS_FT_FI14
|
|
|
72)
|
chain |
B |
| residue |
281 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:22673903
|
| source |
Swiss-Prot : SWS_FT_FI14
|
|
|
73)
|
chain |
C |
| residue |
281 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:22673903
|
| source |
Swiss-Prot : SWS_FT_FI14
|
|
|
74)
|
chain |
A |
| residue |
128 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
75)
|
chain |
B |
| residue |
128 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
76)
|
chain |
C |
| residue |
128 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
77)
|
chain |
A |
| residue |
232 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
78)
|
chain |
B |
| residue |
232 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
79)
|
chain |
C |
| residue |
232 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
80)
|
chain |
A |
| residue |
234 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
81)
|
chain |
B |
| residue |
234 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
82)
|
chain |
C |
| residue |
234 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
|