eF-site ID 4rji-ABCD PDB Code 4rji Chain A, B, C, D click to enlarge Title Acetolactate synthase from Bacillus subtilis bound to ThDP - crystal form I Classification LYASE Compound Acetolactate synthase Source Bacillus subtilis PY79 (V5MX36_BACIU) Sequence A:  NRGAELVVDCLVEQGVTHVFGIPGAKIDAVFDALQDKGPE IIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLAT GLLTANTEGDPVVALAGNVIRADRLKRTHQSLDNAALFQP ITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQD VVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLP VVLVGMKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSR DLEDQYFGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYDP KFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTIN HIEHDAVKVEFAEREQKILSDLKQYMHEGESDRAHPLEIV KELRNAVDDHVTVTCDIGSHAIWMSRYFRSYEPLTLMISN GMQTLGVALPWAIGASLVKPGEKVVSVSGDGGFLFSAMEL ETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFG NIDIVKYAESFGATGLRVESPDQLADVLRQGMNAEGPVII DVPVDYSDNINLASDKLPK B:  NRGAELVVDCLVEQGVTHVFGIPGAKIDAVFDALQDKGPE IIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLAT GLLTANTEGDPVVALAGNVIRADRLKRTHQSLDNAALFQP ITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQD VVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLP VVLVGMKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSR DLEDQYFGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYDP KFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTIN HIEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDR AHPLEIVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYEP LTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGDGGF LFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNR TSAVDFGNIDIVKYAESFGATGLRVESPDQLADVLRQGMN AEGPVIIDVPVDYSDNINLASDKLPKEFGELM C:  KNRGAELVVDCLVEQGVTHVFGIPGAKIDAVFDALQDKGP EIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLA TGLLTANTEGDPVVALAGNVIRADRLKRTHQSLDNAALFQ PITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQ DVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKL PVVLVGMKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLS RDLEDQYFGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYD PKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTI NHIEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSD RAHPLEIVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYE PLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGDGG FLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYN RTSAVDFGNIDIVKYAESFGATGLRVESPDQLADVLRQGM NAEGPVIIDVPVDYSDNINLASDKLPKEFGELMKT D:  KNRGAELVVDCLVEQGVTHVFGIPGAKIDAVFDALQDKGP EIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLA TGLLTANTEGDPVVALAGNVIRADRLKRTHQSLDNAALFQ PITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQ DVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKL PVVLVGMKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLS RDLEDQYFGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYD PKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTI NHIEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSD RAHPLEIVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYE PLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGDGG FLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYN RTSAVDFGNIDIVKYAESFGATGLRVESPDQLADVLRQGM NAEGPVIIDVPVDYSDNINLASDKLPKEFGELMKT Description Functional site 1) chain A residue 400 type sequence S description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 2) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 3) chain A residue 424 type sequence Q description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 4) chain A residue 426 type sequence L description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 5) chain A residue 450 type sequence G description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 6) chain A residue 451 type sequence D description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 7) chain A residue 452 type sequence G description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 8) chain A residue 453 type sequence G description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 9) chain A residue 478 type sequence D description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 10) chain A residue 480 type sequence T description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 11) chain A residue 481 type sequence Y description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 12) chain A residue 482 type sequence D description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 13) chain A residue 483 type sequence M description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 14) chain A residue 484 type sequence V description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 15) chain A residue 547 type sequence Y description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 16) chain B residue 37 type sequence P description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 17) chain B residue 61 type sequence E description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 18) chain B residue 87 type sequence P description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 19) chain B residue 91 type sequence N description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 20) chain B residue 124 type sequence Q description BINDING SITE FOR RESIDUE TPP A 1000 source : AC1 21) chain A residue 451 type sequence D description BINDING SITE FOR RESIDUE MG A 1001 source : AC2 22) chain A residue 478 type sequence D description BINDING SITE FOR RESIDUE MG A 1001 source : AC2 23) chain A residue 480 type sequence T description BINDING SITE FOR RESIDUE MG A 1001 source : AC2 24) chain A residue 37 type sequence P description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 25) chain A residue 61 type sequence E description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 26) chain A residue 87 type sequence P description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 27) chain A residue 91 type sequence N description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 28) chain A residue 124 type sequence Q description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 29) chain B residue 400 type sequence S description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 30) chain B residue 401 type sequence H description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 31) chain B residue 424 type sequence Q description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 32) chain B residue 426 type sequence L description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 33) chain B residue 450 type sequence G description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 34) chain B residue 451 type sequence D description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 35) chain B residue 452 type sequence G description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 36) chain B residue 453 type sequence G description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 37) chain B residue 478 type sequence D description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 38) chain B residue 480 type sequence T description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 39) chain B residue 481 type sequence Y description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 40) chain B residue 482 type sequence D description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 41) chain B residue 483 type sequence M description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 42) chain B residue 547 type sequence Y description BINDING SITE FOR RESIDUE TPP B 601 source : AC3 43) chain B residue 451 type sequence D description BINDING SITE FOR RESIDUE MG B 602 source : AC4 44) chain B residue 478 type sequence D description BINDING SITE FOR RESIDUE MG B 602 source : AC4 45) chain B residue 480 type sequence T description BINDING SITE FOR RESIDUE MG B 602 source : AC4 46) chain B residue 162 type sequence G description BINDING SITE FOR RESIDUE PG4 B 603 source : AC5 47) chain B residue 191 type sequence P description BINDING SITE FOR RESIDUE PG4 B 603 source : AC5 48) chain C residue 162 type sequence G description BINDING SITE FOR RESIDUE PG4 B 603 source : AC5 49) chain C residue 191 type sequence P description BINDING SITE FOR RESIDUE PG4 B 603 source : AC5 50) chain C residue 400 type sequence S description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 51) chain C residue 401 type sequence H description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 52) chain C residue 424 type sequence Q description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 53) chain C residue 450 type sequence G description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 54) chain C residue 451 type sequence D description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 55) chain C residue 452 type sequence G description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 56) chain C residue 453 type sequence G description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 57) chain C residue 478 type sequence D description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 58) chain C residue 480 type sequence T description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 59) chain C residue 481 type sequence Y description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 60) chain C residue 482 type sequence D description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 61) chain C residue 483 type sequence M description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 62) chain C residue 484 type sequence V description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 63) chain C residue 547 type sequence Y description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 64) chain D residue 37 type sequence P description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 65) chain D residue 61 type sequence E description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 66) chain D residue 87 type sequence P description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 67) chain D residue 91 type sequence N description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 68) chain D residue 124 type sequence Q description BINDING SITE FOR RESIDUE TPP C 1000 source : AC6 69) chain C residue 451 type sequence D description BINDING SITE FOR RESIDUE MG C 1001 source : AC7 70) chain C residue 478 type sequence D description BINDING SITE FOR RESIDUE MG C 1001 source : AC7 71) chain C residue 480 type sequence T description BINDING SITE FOR RESIDUE MG C 1001 source : AC7 72) chain C residue 36 type sequence I description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 73) chain C residue 37 type sequence P description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 74) chain C residue 61 type sequence E description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 75) chain C residue 87 type sequence P description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 76) chain C residue 91 type sequence N description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 77) chain C residue 124 type sequence Q description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 78) chain D residue 399 type sequence G description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 79) chain D residue 400 type sequence S description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 80) chain D residue 401 type sequence H description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 81) chain D residue 424 type sequence Q description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 82) chain D residue 426 type sequence L description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 83) chain D residue 450 type sequence G description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 84) chain D residue 451 type sequence D description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 85) chain D residue 452 type sequence G description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 86) chain D residue 453 type sequence G description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 87) chain D residue 478 type sequence D description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 88) chain D residue 480 type sequence T description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 89) chain D residue 481 type sequence Y description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 90) chain D residue 482 type sequence D description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 91) chain D residue 483 type sequence M description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 92) chain D residue 484 type sequence V description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 93) chain D residue 547 type sequence Y description BINDING SITE FOR RESIDUE TPP D 1000 source : AC8 94) chain D residue 451 type sequence D description BINDING SITE FOR RESIDUE MG D 1001 source : AC9 95) chain D residue 478 type sequence D description BINDING SITE FOR RESIDUE MG D 1001 source : AC9 96) chain D residue 480 type sequence T description BINDING SITE FOR RESIDUE MG D 1001 source : AC9 97) chain A residue 434-453 type prosite sequence IGASLVKPGEKVVSVSGDGG description TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGaslvkPgekvVsVsGDGG source prosite : PS00187

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