eF-site ID 4rjf-C PDB Code 4rjf Chain C click to enlarge Title Crystal structure of the human sliding clamp at 2.0 angstrom resolution Classification REPLICATION Compound Proliferating cell nuclear antigen Source Homo sapiens (Human) (CDN1A_HUMAN) Sequence C:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI SCAKDGVKFSASGELGNGNIKLSQTSNKEEEAVTIEMNEP VQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIA DMGHLKYYLAPKI Description Functional site 1) chain C residue 254 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 2) chain C residue 77 type MOD_RES sequence K description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973 source Swiss-Prot : SWS_FT_FI3 3) chain C residue 80 type MOD_RES sequence K description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973 source Swiss-Prot : SWS_FT_FI3 4) chain C residue 248 type MOD_RES sequence K description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973 source Swiss-Prot : SWS_FT_FI3 5) chain C residue 211 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032 source Swiss-Prot : SWS_FT_FI4 6) chain C residue 164 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289 source Swiss-Prot : SWS_FT_FI5

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