eF-site ID 4rid-AB PDB Code 4rid Chain A, B click to enlarge Title Human FAN1 nuclease Classification HYDROLASE Compound Fanconi-associated nuclease 1 Source Homo sapiens (Human) (FAN1_HUMAN) Sequence A:  TGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQ LSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEE LTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNP NGQKQQLVDAFLKLAKQRSVIGAVILKRAKALAGQSVRIC KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVN LGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSA MANGNWEEAKELAQCAKRDWNRLKNHPSLRCHEDLPLFLR CFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQRI YCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEV RTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVK HVTITGRLCKSVFVMVLCSVEELALAHYRRSGFDQGIHGE GSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDS FFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVA SLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHC RGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAEL QKLGAEVEVCHVVAV B:  TGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQ LSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEE LTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNP NGQKQQLVDAFLKLAKQRSVIGAVILKRAKALAGQSVRIC KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVN LGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSA MANGNWEEAKELAQCAKRDWNRLKNHPSLRCHEDLPLFLR CFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQRI YCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEV RTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVK HVTITGRLCPQRKSVFVMEAGEAADPTTVLCSVEELALAH YRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRN ACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAW VAATWHEQEGRVASLVSWDRFTSLQQAQDLVSCLGGPVLS GVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPND RLSHKQMIWLAELQKLGAEVEVCHVVAV Description Functional site 1) chain A residue 834 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 960 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 975 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 976 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 834 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 960 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1 7) chain B residue 975 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 976 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:Q9I2N0 source Swiss-Prot : SWS_FT_FI1

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