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eF-site ID
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4rid-A |
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PDB Code
|
4rid |
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Chain
|
A |
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click to enlarge
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Title
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Human FAN1 nuclease |
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Classification
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HYDROLASE |
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Compound
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Fanconi-associated nuclease 1 |
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Source
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Homo sapiens (Human) (FAN1_HUMAN) |
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Sequence
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A: |
TGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQ
LSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEE
LTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNP
NGQKQQLVDAFLKLAKQRSVIGAVILKRAKALAGQSVRIC
KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVN
LGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSA
MANGNWEEAKELAQCAKRDWNRLKNHPSLRCHEDLPLFLR
CFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQRI
YCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEV
RTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVK
HVTITGRLCKSVFVMVLCSVEELALAHYRRSGFDQGIHGE
GSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDS
FFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVA
SLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHC
RGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAEL
QKLGAEVEVCHVVAV
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Description
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Functional site
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1)
|
chain |
A |
| residue |
834 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:Q9I2N0
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
960 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:Q9I2N0
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
975 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:Q9I2N0
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
976 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000250|UniProtKB:Q9I2N0
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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|
|