eF-site ID 4ri5-B PDB Code 4ri5 Chain B click to enlarge Title Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 3 Source (PTN3_HUMAN) Sequence B:  SNADTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT TLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYV SREMLVTNTQTGEEHTVTHLQYVAWPEHGVPDDSSDFLEF VNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTER NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE GLVQ Description Functional site 1) chain B residue 676 type sequence Y description BINDING SITE FOR RESIDUE GOL B 1001 source : AC3 2) chain B residue 812 type sequence H description BINDING SITE FOR RESIDUE GOL B 1001 source : AC3 3) chain B residue 886 type sequence Q description BINDING SITE FOR RESIDUE GOL B 1001 source : AC3 4) chain B residue 842 type sequence C description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 5) chain B residue 843 type sequence S description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 6) chain B residue 844 type sequence A description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 7) chain B residue 845 type sequence G description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 8) chain B residue 846 type sequence I description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 9) chain B residue 847 type sequence G description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 10) chain B residue 848 type sequence R description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 11) chain B residue 886 type sequence Q description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 12) chain B residue 842 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 842 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 886 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 811 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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